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Alkynylamino-nucleotides

  • US 5,047,519 A
  • Filed: 06/12/1987
  • Issued: 09/10/1991
  • Est. Priority Date: 07/02/1986
  • Status: Expired due to Term
First Claim
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1. An alkynylamino-nucleotide having the structure:

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    space="preserve" listing-type="equation">Nuc--C.tbd.C--R.sub.1 --NR.sub.2 R.sub.3whereinR1 is a diradical moiety of 1-20 atoms,R2 and R3 are, independently, H, C1 -C4 alkyl or a protecting group, and Nuc is R4 -Het having the structure ##STR16## Z is H or NH2, and R4 is ##STR17## wherein R5 is H, PO3 H2, P2 O6 H3, P3 O9 H4 or salts thereof, and(i) when R7

    R8

    H, then R6

    H, OH, F, N3 or NH2 ;

    or(ii) when R7

    H and R8

    OH, then R6

    H or OH;

    or(iii) when R7

    OH and R8

    H, then R6

    OH.

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