Ophthalmic solution for intraocular pressure adjustment

• US 5,049,587 A
• Filed: 04/21/1989
• Issued: 09/17/1991
• Est. Priority Date: 04/21/1988
• Status: Expired due to Fees

• Current Assignee: Basotherm GmbH (Gesparal SA)
• Original Assignee: Basotherm GmbH (Gesparal SA)
• Inventors: Yajima, Motoyuki, Okamoto, Taira
• Primary Examiner(s): Friedman, Stanley J.
• Assistant Examiner(s): FAY, ZOHREH A
• Application Number:
  US07/341,408
• Time in Patent Office: 879 Days
• Field of Search: 514/466, 514/653
• US Class Current: 514/653
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics

Abstract

Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.

Claims

1. A method for lowering intraocular pressure which comprises instilling into the eye an opthalmic solution comprising an intraocular pressuring lowering amount of a compound of the formula II ##STR4## wherein R₁ is hydrogen, fluorine, chlorine, bromine, iodine or cyano;

R₂ is fluorine, trifluoromethyl, nitro or cyano; and

R₃ is alkyl of 3 to 5 carbon atoms, hydroxyalkyl of 3 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl;

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 wherein the compound of formula II is 1-(4'"'"'-amino-3'"'"'-chloro-5'"'"'trifluoromethyl-phenyl-2-tert.-butylaminoethanol or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 or 2 wherein the amount of the compound of formula II instilled is between about 1.10^-6 and 2.0 mg.