Blood cell washing systems and methods
First Claim
1. A system in which shed blood containing contaminants is processed to a red cell concentrate having reduced contaminants, said system comprising:
- first filter means for receiving the shed blood and passing it longitudinally through a gap which extends adjacent a first filtration membrane of less than 1.2 micron pore size, the first filter means providing a filtered waste product and an intermediate cell concentrate product;
fluid flow control means receiving the intermediate cell concentrate product and providing a buffer supply thereof; and
second filter means coupled to the fluid flow control means for receiving the intermediate cell concentrate product and passing it longitudinally through a gap which extends adjacent a second filtration membrane of less than 1.2 micron pore size, wherein the second filter means is for mixing a saline solution with the intermediate cell concentrate within the gap to provide a washed red cell concentrate.
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Abstract
A system and method for cleaning contaminants from shed blood to enable reinfusion of a cell concentrate in the patient employs successive rotary membrane filtering stages in which Taylor vortices are generated. Shed blood led into the first rotary membrane stage is filtered to produce a hematocrit in the range of 50-60 with some of the waste matter being removed. The intermediate cell concentrate is passed to the second filter stage where further waste matter is initially extracted. At any intermediate region, however, a major amount of wash solution is fed into the concentrate and effectively mixed therein. In the remaining length of the second filter stage, waste matter is entrained in the wash solution and both waste and wash solution are filtered out to provide a cell concentrate from which the great majority of contaminants have been removed.
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Citations
20 Claims
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1. A system in which shed blood containing contaminants is processed to a red cell concentrate having reduced contaminants, said system comprising:
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first filter means for receiving the shed blood and passing it longitudinally through a gap which extends adjacent a first filtration membrane of less than 1.2 micron pore size, the first filter means providing a filtered waste product and an intermediate cell concentrate product; fluid flow control means receiving the intermediate cell concentrate product and providing a buffer supply thereof; and second filter means coupled to the fluid flow control means for receiving the intermediate cell concentrate product and passing it longitudinally through a gap which extends adjacent a second filtration membrane of less than 1.2 micron pore size, wherein the second filter means is for mixing a saline solution with the intermediate cell concentrate within the gap to provide a washed red cell concentrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A disposable apparatus for use in washing and filtering blood constituents, said apparatus comprising:
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a cardiotomy reservoir for temporary storage of input blood constituents; a first rotatable filter coupled to receive fluid from said cardiotomy reservoir; a pooling reservoir coupled to receive filtration concentrate from said first rotatable filter; and a second rotatable filter having an input coupled to receive filtration concentrate from said pooling reservoir, and having a washing solution inlet for receiving a washing solution and coupling the washing solution into mixing relationship with the received filtration concentrate. - View Dependent Claims (13, 14, 15)
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16. A disposable apparatus for use in washing and filtering blood constituents, said apparatus comprising:
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a first rotatable filter having a fluid input for receiving blood to be washed and filtered, a filtrate output and a cell concentrate output; a second rotatable filter having a fluid input, a filtrate output, a cell concentrate output and a washing liquid input disposed intermediate said fluid input and said cell concentrate output; the cell concentrate output of said first filter being in fluid communication with the blood fluid input of the second filter. - View Dependent Claims (17, 18)
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19. A blood constituent washing and filtering apparatus, comprising:
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a rotatable, generally cylindrical, blood constituent filtering membrane disposed within a stationary housing and defining a longitudinally extending annular gap therebetween in which Couette fluid flow, having Taylor vortices, can be established; a fluid inlet port to said gap; a fluid concentrate outlet port from said gap being longitudinally spaced apart from said fluid inlet port; a washing solution inlet port to said gap longitudinally disposed intermediate said fluid inlet port and said fluid concentrate port and closer to said fluid inlet port than to said fluid concentrate output port. - View Dependent Claims (20)
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Specification