Osteogenesis promotion with use of vitamin D derivatives
First Claim
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1. A method for promoting osteogenesis without causing hypercalcemia, comprising:
- administering to a person in need of osteogenesis an amount effective to promote osteogenesis without causing hypercalcemia of 1α
,3β
-dihydroxy-20α
-(3-hydroxy-3-methylbuthyloxy)-9,10-seco-5,7,10(19)-pregnatriene.
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Abstract
An osteogenesis promotion with use of a vitamin D derivative of the formula: ##STR1## wherein R1, R2 and R3, which may be the same or different, each represents a hydrogen atom or a hydroxyl group; and R4 is a hydrogen atom or a lower alkyl group having 4-6 carbon atoms that may or may not be substituted by a hydroxyl group, are disclosed. A pharmaceutical composition comprising the above derivatives is useful as a therapeutic agent for osteoporosis.
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Citations
3 Claims
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1. A method for promoting osteogenesis without causing hypercalcemia, comprising:
administering to a person in need of osteogenesis an amount effective to promote osteogenesis without causing hypercalcemia of 1α
,3β
-dihydroxy-20α
-(3-hydroxy-3-methylbuthyloxy)-9,10-seco-5,7,10(19)-pregnatriene.- View Dependent Claims (2, 3)
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Current AssigneeChugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
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Original AssigneeChugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
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InventorsNishii, Yasuho, Matsumoto, Toshio
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Primary Examiner(s)Rose, Shep K.
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Application NumberUS07/485,702Time in Patent Office581 DaysField of Search514/167US Class Current514/167CPC Class CodesA61K 31/59 Compounds containing 9, 10-...
