Liver function testing apparatus

• US 5,054,916 A
• Filed: 11/08/1988
• Issued: 10/08/1991
• Est. Priority Date: 11/13/1987
• Status: Expired due to Fees

• Current Assignee: Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Original Assignee: Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Inventors: Kanda, Masahiko, Awazu, Kunio
• Primary Examiner(s): Rosenberger, Richard A.
• Assistant Examiner(s): Pham, Hoa
• Application Number:
  US07/268,735
• Time in Patent Office: 1,064 Days
• Field of Search: 356/39-42, 356/51, 356/72, 356/410, 356/418, 356/320, 356/39, 250/218, 250/528, 128/665-667, 128/633
• US Class Current: 356/39
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/4244 liver

Abstract

In a liver function testing apparatus, light sources (11, 12) expose vital tissue (15) to first light of a wavelength capable of being absorbed by a specific dye dosed into blood of the vital tissue to be taken in and removed by the liver, and second light of a wavelength not capable of being absorbed by the specific dye. Optical pulses obtained from the vital tissue are received by a light receiving element (13), the output of which is sampled by an A/D converter (30) for converting the analog output signals into digital signals. A biocalibration is preformed on the basis of variable components in the blood. For this purpose a CPU (34) determines coefficients for first and second regression line expressions before and after an injection of the specific dye. The coefficients are provided by first and second photoelectric conversion signals. A value correlated with a specific dye concentration in the blood is processed on the basis of sampling signals during a prescribed period after injecton of the specific dye to provide the coefficients for the regression line expressions. The obtained coefficients are processed by using the method of least squares for obtaining a blood plasma disappearance rate of the specific dye and a retention rate for a prescribed length of time following an injection.

Claims

1. A liver function testing apparatus for testing a liver function, comprising:

light source means (11,

     12) for exposing vital tissue to a first light signal capable of being absorbed by a specific dye injected into blood of said vital tissue, said dye to be taken in and removed by the liver, and to a second light signal capable of not being absorbed by said specific dye;

photoelectric conversion means (13) for outputting first and second photoelectric conversion signals obtained from said vital tissue and corresponding to said first light signal and to said second light signal applied to said vital tissue by said light source means;

sampling means (28) for sampling said first and second photoelectric conversion signals a plurality of times;

first decision means (34, SP28) for determining a first coefficient of a first regression line expression between said first and second photoelectric conversion signals on the basis of variable components in said blood included in said first and second photoelectric conversion signals sampled by said sampling means a plurality of times before injection of said specific dye;

second decision means (34, SP28) for determining a second coefficient of a second regression line expression between said first and second photoelectric conversion signals on the basis of variable components in said blood included in said first and second photoelectric conversion signals sampled by said sampling means a plurality of times after a lapse of a prescribed period; and

arithmetic means (34) for storing a plurality of sampling signal outputs of said sampling means during a prescribed period of time following said injection of said specific dye for processing a value correlated with a specific dye concentration in said blood on the basis of said first and second coefficients of said first and second regression line expressions determined by first and second decision means for obtaining a coefficient of a simulation function as a function of time by using the method of least squares on the basis of said processed value correlated with said specific dye concentration, for obtaining a blood plasma disappearance rate of said specific dye and a retention rate of said specific dye in said prescribed period of time on the basis of said simulation function coefficient.

2. The liver function testing apparatus in accordance with claim 1, wherein

said second decision means determines (SP28) said second coefficient within a prescribed period following an injection of said specific dye in an arbitrary short period after a time when said specific dye is uniformly distributed in said blood.

3. The liver function testing apparatus in accordance with claim 1, wherein said arithmetic means includes means (SP48) for obtaining first dimensionless constants A₁ and B₁ by performing a regression line analysis in accordance with the following operation expression:

space="preserve" listing-type="equation">logCL.sub.1 =A.sub.1 ·

logCL.sub.2 +B.sub.1,

wherein CL₁ and CL₂ represent average voltage values of said first and second photoelectric conversion signals sampled by said sampling means a plurality of times before injection of said specific dye, and obtaining second dimensionless constants A₂ and B₂ by performing a regression line analysis in accordance with the following operation expression;

space="preserve" listing-type="equation">logCL.sub.1 '"'"'=A.sub.2 ·

logCL.sub.2 '"'"'+B.sub.2,

wherein CL₁ '"'"' and CL₂ '"'"' represent average values of said first and second photoelectric conversion signals sampled by said sampling means a plurality of times after a lapse of a prescribed period following an injection of said specific dye, for obtaining;

space="preserve" listing-type="equation">logL.sub.10 =(A.sub.1 ·

B.sub.2 -A.sub.2 ·

B.sub.1)/(A.sub.1 -A.sub.2)

as a blood-free point signifying that said tissue is substantially free of blood.

4. The liver function testing apparatus in accordance with claim 3, wherein said arithmetic means includes means (SP48) for processing a value Cg correlated with said specific dye concentration on the basis of said constants A₁ and B₁ and said blood-free point L₁₀ in accordance with the following operation expression:

##EQU4##

5. The liver function testing apparatus in accordance with claim 4, wherein said arithmetic means includes means (SP48) for processing first constants A₁ and B₁ by performing a regression line analysis in accordance with the following operation expression:

space="preserve" listing-type="equation">logCL.sub.1 =A.sub.1 ·

logCL.sub.2 +B.sub.1,

wherein CL₁ and CL₂ represent average voltage values of said first and second photoelectric conversion signals sampled by said sampling means a plurality of times before injection of said specific dye, for obtaining second constants A₂ and B₂ by performing a regression line analysis in accordance with the following operation expression;

space="preserve" listing-type="equation">logCL.sub.1 '"'"'=A.sub.2 ·

logCL.sub.2 '"'"'+B.sub.2,

wherein CL₁ '"'"' and CL₂ '"'"' represent average voltage values of said first and second photoelectric conversion signals sampled by said sampling means a plurality of times within a prescribed period of time after injection of said specific dye in an arbitrary period after a time when said specific dye is uniformly distributed in said blood, for obtaining;

space="preserve" listing-type="equation">logL.sub.10 =(A.sub.1 ·

B.sub.2 -A.sub.2 ·

B.sub.1)/(A.sub.1 -A.sub.2)

as a blood-free point signifying that said tissue is substantially free of blood.

6. The liver function testing apparatus in accordance with claim 4, wherein said arithmetic means includes means (SP51) for processing constants A and B on the basis of the following operation expression:

space="preserve" listing-type="equation">Cg=Ae.sup.-Bt,

wherein t represents said prescribed period of time after injection of said specific dye.

7. The liver function testing apparatus in accordance with claim 1, wherein said arithmetic means includes means (SP52) for solving the following operation expression:

space="preserve" listing-type="equation">K=B,

said solving operation being based on the fact that k represents said blood plasma disappearance rate.

8. The liver function testing apparatus in accordance with claim 1, wherein said arithmetic means includes means (SP52) for solving the following operation expression:

space="preserve" listing-type="equation">R%=e.sup.-BT,

wherein R % represents said retention rate.

9. The liver function testing apparatus in accordance with claim 1, wherein

said decision means includes means for processing a correlation coefficient of said regression line expression,

said liver function testing apparatus further including informing means (33) for giving an alarm when said correlation coefficient processed by said means for operating said correlation coefficient is greater than a predetermined value.

10. The liver function testing apparatus in accordance with claim 1, wherein

said arithmetic means includes means for processing correlation coefficient of said simulation function,

said liver function testing apparatus further including informing means (33) for giving an alarm when said correlation coefficient of said simulation function is greater than a predetermined value.

11. The liver function testing apparatus in accordance with claim 1, further including mode selection means (41, 42) for selecting a biocalibration mode for performing an operation for determining said coefficient of said regression line expression by said decision means, and a measurement mode for performing an operation for processing said value correlated with said specific dye concentration by said arithmetic means.

12. The liver function testing apparatus in accordance with claim 11, further including arithmetic means for activating said decision means in response to a selection of said biocalibration mode by said mode selection means.

13. The liver function testing apparatus in accordance with claim 12, wherein said arithmetic means (34) include means for activating said arithmetic means in response to a selection of a measurement mode by said mode selection means.

14. The liver function testing apparatus in accordance with claim 1, further including set means (SP241-SP249) for setting intensity levels of said first light signal and said second light signal emitted from said light source means so that levels of said first and second photoelectric conversion signals are within a predetermined range.