Time release protein

• US 5,055,300 A
• Filed: 06/05/1989
• Issued: 10/08/1991
• Est. Priority Date: 06/17/1988
• Status: Expired due to Term

• Current Assignee: Basic Bio Systems, Inc.
• Original Assignee: Basic Bio Systems, Inc.
• Inventors: Gupta, Kashmiri L.
• Primary Examiner(s): Page, Thurman
• Assistant Examiner(s): Benston, William E.
• Application Number:
  US07/362,034
• Time in Patent Office: 855 Days
• Field of Search: 424/491, 424/499, 424/488, 424/489, 424/484, 424/485, 424/497, 424/409, 426/656, 514/963
• US Class Current: 424/409
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/26 in coated particulate form
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0279 Porous; Hollow
• CPC Class Codes: A61K 8/645 Proteins of vegetable origin; Derivatives or degradation products thereof
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61L 9/04 using substances evaporated in the air without heating
• CPC Class Codes: A61L 9/042 with the help of a macromolecular compound as a carrier or diluent A61L9/048 takes precedence
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

Disclosed is a porous protein particle for delivering over a period of time an active ingredient impregnated therein, and methods of making and using the same. The protein particles have a median size less than about 50 microns. Active ingredient entrapped in the porous structure is gradually released from the protein particle.

Claims

1. A time release delivery vehicle for delivering an active ingredient, comprising a multiplicity of discrete natural, unhydrolyzed seed protein particles in powder form from which lipids naturally found in said seeds have been separated, each said particle having a network of pores with the active ingredient impregnated into the pores of said particles in such a manner that the active ingredient can migrate out of said pores in a controlled manner to release active ingredient over a period of at least 20 minutes.

2. A time release delivery vehicle as in claim 1, wherein the protein particles are biodegradable.

3. A time release delivery vehicle as in claim 1, wherein the protein particle is derived from natural grains or legumes.

4. A time release delivery vehicle as in claim 1, wherein the protein particles are of irregular shape.

5. A time release delivery vehicle as in claim 3, wherein the grain or legume is selected from the group consisting of canola, beans, oats, rape seed, soya, peas, and wheat.

6. A time release delivery vehicle as in claim 1, wherein the median particle size is less than about 50 microns.

7. A time release delivery vehicle as in claim 1, further comprising an outer layer encapsulating the protein particles and having the active ingredient contained therein.

8. A time release delivery vehicle as in claim 7, wherein the outer layer is impermeable to the active ingredient.

9. A time release delivery vehicle as in claim 7, wherein the outer layer comprises a porous polymer.

10. A time release delivery vehicle as in claim 6, wherein the median particle size is within the range of from about 0.1 to 50 microns.

11. A time release vehicle as in claim 1, wherein amino or carboxyl groups or both, of the protein have been derivatized to alter the release characteristics of active ingredient from the release characteristics possessed by the protein particles in underivatized form.