Iontophoresis electrode

• US 5,057,072 A
• Filed: 11/21/1990
• Issued: 10/15/1991
• Est. Priority Date: 10/28/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Phipps, Joseph B.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Lewis, Ralph A.
• Application Number:
  US07/616,724
• Time in Patent Office: 328 Days
• Field of Search: 604/20, 604/890.1, 128/783, 128/798, 128/802, 424/447, 424/448, 424/449
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode

Abstract

An improved iontophoresis electrode employing a current distributing member and a drug reservoir containing an ionic drug. The current distribution member is separated from the drug reservoir by means of a membrane or material selective for ions having a charge opposite to the charge of the ionic drug. The selective material is applied directly to the current distributing member.

Claims

1. An iontophoresis electrode comprising:

a conductive, current distributing member;

means for coupling said current distributing member to a source of electrical current;

reservoir means containing an ionic or ionizable drug to be delivered, and being further constructed and arranged to be in electrical contact with the current distributing member; and

a layer of charge selective material applied directly to said current distributing member, and arranged intermediate said current distributing member and said reservoir means and coupling them together.

4. The electrode of claim 1, 2 or 3, wherein the drug to be delivered is cationic or ionizable into cations and the charge selective material is selectively permeable to anions.

5. The electrode of claim 4, wherein the charge selective material applied directly to the current distributing member comprises an anion exchange membrane.

6. The electrode of claim 5, wherein the anion exchange membrane is selected from the group consisting of copolymers of styrene and divinyl benzine reacted with trimethylamine.

7. The electrode of claim 1, 2 or 3, wherein the drug to be delivered is anionic or ionizable into anions and the charge selective material applied directly to the current distributing member is selectively permeable to cations.

8. The electrode of claim 7, wherein the charge selective material applied directly to the current distributing member comprises a cation exchange membrane.

9. The electrode of claim 8, wherein the cation exchange membrane is selected from the group consisting of sulfonated styrene polymers and sulfonated fluorocarbon polymers.

10. The electrode of claim 1 or 3, wherein the current distributing member is comprised of an inert metal.

11. The electrode of claim 10, wherein the inert metal is selected from the group consisting of platinum and stainless steel.

12. The electrode of claim 10, wherein the drug is selected from weak acids and weak bases.

20. The electrode of claim 1, 2 or 3, wherein the reservoir means comprises a nonionic gel.

2. An iontophoresis electrode, comprising:

a current distributing member fabricated of a material which is readily oxidized or reduced at a voltage less than the voltage required to hydrolyze water;

connector means for connecting said current distributing member to a source of electrical current;

reservoir means constructed and arranged for the delivery of drug to skin against which the electrode is contacted, said reservoir means being coupled to said current distributing member, said reservoir means containing an ionic drug compounded with a counterion which reacts with said material of which said current distributing member is fabricated, after said material is oxidized or reduced, to produce a compound insoluble with said reservoir means; and

a layer of charge selective material applied directly to said current distributing member, said material selective for ions of the opposite charge as said ionic drug, said material applied intermediate said current distributing member and said reservoir means and coupling them together.

13. The electrode of claim 2, wherein the drug to be delivered is cationic or ionizable into cations and the current distributing member comprises a material which is oxidizable.

14. The electrode of claim 13, wherein the oxidable material comprises silver.

15. The electrode of claim 14, wherein the counterion comprises chloride and the insoluble compound comprises silver chloride.

16. The electrode of claim 2, wherein the drug to be delivered is anionic or ionizable into anions and the current distributing member comprises a material which is reducible.

17. The electrode of claim 16, wherein the reducible material comprises silver/silver chloride.

18. The electrode of claim 17, wherein the counterion is capable of forming a neutrally charged compound when combined with ionic chlorine.

19. The electrode of claim 18, wherein the counterion is selected from the group consisting of copper and silver.

3. An iontophoresis electrode for delivery of an ionic or ionizable drug to a skin comprising:

a conductive, current distributing member;

means for coupling said current distributing member to a source of electrical current;

reservoir means containing an ionic or ionizable drug to be delivered to said skin, the reservoir means being constructed and arranged for delivery of the drug to skin against which the electrode is contacted;

a layer of first charge selective material applied directly to said current distributing member and contacting the reservoir means whereby the current distributing member and reservoir means are coupled together; and

a second charge selective material located at the interface of the drug reservoir means and the skin, the second charge selective material selectively passing ions having the charge of the drug to be delivered to said skin from the reservoir means.

29. The method of claim 3, wherein the current distributing member is comprised of an inert metal.

30. The method of claim 29, wherein the inert metal is selected from the group consisting of platinum and stainless steel.

31. The method of claim 29, wherein the drug is selected from weak acids and weak bases.

21. A method of fabricating an iontophoresis electrode, comprising the steps of:

selecting an ionic or ionizable drug to be delivered;

including said drug within a reservoir means through which said drug is permeable for delivery to skin against which the electrode is contacted;

selecting a conductive current distributing member;

selecting a charge selective material selectively permeable to ions of the charge opposite to that of said drug; and

assembling said electrode by applying said charge selective material directly to said current distributing member and mounting said current distributing member to said reservoir such that said charge selective material is located intermediate said current distributing member and said reservoir.

22. A method of fabricating an iontophoresis electrode, comprising the steps of:

selecting an ionic drug to be delivered;

selecting a sacrificial current distributing member fabricated of a material readily oxidizable or reducible by application of a voltage less than required to hydrolyze water;

compounding said ionic drug with a counterion which will react with the material of which said current distributing member is fabricated, after said material is oxidized or reduced, to form a neutral compound, and placing said compounded ionic drug into a reservoir means through which said ionic drug is permeable for delivery to skin against which the electrode is contacted; and

applying a charge selective material directly to said current distributing member, said charge selective material permeable to ions having the charge opposite to the charge of said ionic drug, said charge selective material applied between said current distributing member and said reservoir.

23. The method of claim 3 or 22, wherein the drug to be delivered is cationic or ionizable into cations and the charge selective material is selectively permeable to anions.

24. The method of claim 23, wherein the charge selective material applied directly to the current distributing member comprises an anion exchange membrane.

25. The method of claim 24, wherein the anion exchange membrane is selected from the group consisting of copolymers of styrene and divinyl benzene reacted with trimethylamine.

26. The method of claim 3 or 22, wherein the drug to be delivered is anionic or ionizable into anions and the charge selective material applied directly to the current distributing member is selectively permeable to cations.

27. The method of claim 26, wherein the charge selective material applied directly to the current distributing member comprises a cation exchange membrane.

28. The method of claim 27, wherein the cation exchange membrane is selected from the group consisting of sulfonated styrene polymers and sulfonated fluorocarbon polymers.

32. The method of claim 22, wherein the drug to be delivered is cationic or ionizable into cations and the current distributing member comprises a material which is oxidizable.

33. The method of claim 32, wherein the oxidizable material comprises silver.

34. The method of claim 33, wherein the counterion comprises chloride and the insoluble compound comprises silver chloride.

35. The method of claim 22, wherein the drug to be delivered is anionic or ionizable into anions and the current distributing member comprises a material which is reducible.

36. The method of claim 35, wherein the reducible material comprises silver/silver chloride.

37. The method of claim 36, wherein the counterion is capable of forming a neutrally charged compound when combined with ionic chlorine.

38. The method of claim 37, wherein the counterion is selected from the group consisting of copper and silver.

39. The method of claim 3 or 22, wherein the reservoir means comprises a nonionic gel.