Delivery system for beneficial agent over a broad range of rates

• US 5,057,318 A
• Filed: 04/20/1990
• Issued: 10/15/1991
• Est. Priority Date: 12/13/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Perry, John R., Cortese, Richard
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): HORNE, LEON
• Application Number:
  US07/513,327
• Time in Patent Office: 543 Days
• Field of Search: 424/473, 424/422, 424/423, 424/484, 424/486, 424/426, 424/438
• US Class Current: 424/438
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

Claims

1. The delivery system for delivering the beneficial agent to an environment of use, the delivery system comprising:

(a) a first section comprising a wall that surrounds an internal lumen and comprises an open end, said wall comprising a member selected from the group consisting of a polymer, glass and stainless steel composition that restricts the passage of fluid into the internal lumen;

(b) a second section comprising a wall that surrounds an internal lumen and comprises an enlarged open end that receives the end of the first section, said wall comprising a polymer composition that is permeable to the passage of fluid;

(c) a beneficial agent in the first section;

(d) an expandable member in the second section; and

(e) at least on exit passageway in the delivery system for delivering the beneficial agent to the environment of use.

2. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is somatotropin.

3. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is porcine somatotropin.

4. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the delivery system is an implant.

5. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the lumen comprises glycerol.

6. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the lumen comprises a surfactant.

7. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the lumen comprises a buffer.

8. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein a wax interfaces the phosphate buffer.

9. A delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the composition substantially impermeable to fluid is between the beneficial agent and the expandable member.

10. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein a wax interfaces the beneficial agent and the expandable member.

11. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the exit passageway is closed by a means for closing said passageway.

12. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the exit passageway is formed by removing means for forming said passageway.

13. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the exit passageway is exposed by removing means for exposing said passageway.