Multiple monopolar system and method of measuring stroke volume of the heart

• US 5,058,583 A
• Filed: 07/13/1990
• Issued: 10/22/1991
• Est. Priority Date: 07/13/1990
• Status: Expired due to Fees

• Current Assignee: Purdue Research Foundation (Purdue University)
• Original Assignee: Jerry L. Wessale, Leslie A. Geddes, Neal E. Fearnot
• Inventors: Wessale, Jerry L., Fearnot, Neal E., Geddes, Leslie A.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/553,434
• Time in Patent Office: 466 Days
• Field of Search: 128/419 PG, 128/419 P, 128/419 D, 128/734, 128/693
• US Class Current: 607/6
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/3686 configured for selecting the electrode configuration on a lead A61N1/3688 takes precedence

Abstract

A multiple monopolar system and method for measuring stroke volume of a patient'"'"'s heart. An intracardiac impedance catheter is provided with a plurality of monopolar electrodes axially spaced along the surface of its distal end, and is used in conjunction with a distant reference electrode which may, for example, be incorporated into the conductive case of a pacemaker. The proximal end of the catheter is attached to the pacemaker, which, in addition to pulse generator circuitry and circuitry for sensing electrical activity of the heart and for controlling pacing rate, includes a constant-current source for current injection into the volume of blood in the patient'"'"'s ventricle and an impedance processor for measuring the resultant voltage between one of the monopolar electrodes in the ventricle and the pacemaker case and for calculating stroke volume therefrom. A system and method are also disclosed for generating a three-phase relationship between cardiac output and heart rate for an individual patient at a particular workload, for purposes of determining optimal heart rate, as is a method of using the monopolar electrode configuration to detect ventricular fibrillation.

Claims

1. A multiple monopolar system for measuring the stroke volume of a patient'"'"'s heart, comprising:

an intracardiac impedance catheter having a distal end and a proximal end;

a plurality of same-polarity-monopolar electrodes axially spaced along the surface of said distal end of said impedance catheter;

a reference electrode adapted for positioning distant from said monopolar electrodes in the patient'"'"'s body; and

monopolar means for supplying a drive signal and measuring impedance between each of said monopolar electrodes and said distant reference electrode.

2. A multiple monopolar system for measuring the stroke volume of a patient'"'"'s heart, comprising:

an intracardiac impedance catheter having a distal end and a proximal end;

a plurality of monopolar electrodes axially spaced along the surface of said distal end of said impedance catheter;

a reference electrode adapted for positioning distant from said monopolar electrodes in the patient'"'"'s body;

monopolar means for supplying a drive signal and measuring impedance between each of said monopolar electrodes and said distant reference electrode;

an implantable cardiac device having a conductive case which incorporates said reference electrode, said cardiac device including a pulse generator housed within said case, said case being attached to said proximal end of said catheter;

a stimulating electrode disposed on said distal end of said catheter distal to said monopolar electrodes;

a first electrical conductor connected to said stimulating electrode and extending therefrom within said catheter to said proximal end thereof;

means for electrically connecting said pulse generator to said first electrical conductor; and

a plurality of individual electrical conductors connected to respective ones of said monopolar electrodes and extending therefrom within said catheter to said proximal end thereof;

wherein said monopolar means further includes a current source and an impedance processor housed within said case, and means for electrically connecting an output of said current source and an input of said impedance processor to each of said individual conductors.

3. The multiple monopolar system of claim 2 wherein said monopolar means further includes means for selecting the monopolar electrode whose output is determined to be most representative of stroke volume for a particular patient.

4. The multiple monopolar system of claim 2 wherein said monopolar means further includes means for switching said current source and said impedance processor sequentially between selected ones of said individual conductors;

and

wherein said impedance processor includes means for obtaining a weighted sum of signals appearing on said individual conductors from said monopolar electrodes.

5. The multiple monopolar system of claim 2 wherein said monopolar means further includes means for connecting said current source and said impedance processor simultaneously to said individual conductors.

6. The multiple monopolar system of claim 5 wherein said current source includes means for driving said individual conductors at different frequencies, and wherein said impedance processor includes means for discriminating on the basis of frequency between signals appearing on said individual conductors from said monopolar electrodes.

7. A multiple monopolar method of measuring the stroke volume of a patient'"'"'s heart, comprising the steps of:

introducing into the patient'"'"'s heart an impedance catheter having a plurality of same-polarity-monopolar electrodes axially spaced along the surface of one end;

positioning a reference electrode distant from said monopolar electrodes in the patient'"'"'s body; and

supplying a drive signal and measuring impedance between each of said monopolar electrodes and said distant reference electrode for measuring the stroke volume of said heart.

8. A multiple monopolar method of measuring the stroke volume of a patient'"'"'s heart, comprising the steps of:

introducing into the patient'"'"'s heart an impedance catheter having a plurality of monopolar electrodes axially spaced along the surface of one end;

positioning a reference electrode distant from said monopolar electrodes in the patient'"'"'s body;

supplying a drive signal and measuring impedance between each of said monopolar electrodes and said distant reference electrode;

wherein said supplying step is performed with a current source and an impedance processor housed within a case of an implantable cardiac device, said cardiac device including a pulse generator housed within said case, said case being attached to said proximal end of said catheter;

wherein said catheter includes a stimulating electrode disposed on said distal end thereof distal to said monopolar electrodes, and an electrical conductor connected to said stimulating electrode and extending therefrom within said catheter to said proximal end thereof; and

wherein said supplying step further includes electrically connecting an output of said current source and an input of said impedance processor to each of a plurality of individual electrical conductors connected to respective ones of said monopolar electrodes and extending therefrom within said catheter to said proximal end thereof for measuring the stroke volume of said heart.

9. A multiple monopolar method of claim 8, further comprising the step of selecting the monopolar electrode whose output is determined to be most representative of stroke volume for a particular patient.

10. The multiple monopolar method of claim 8, further comprising the steps of:

switching said current source and said impedance processor sequentially between selected ones of said individual conductors; and

obtaining a weighted sum of signals appearing on said individual conductors from said monopolar electrodes.

11. The multiple monopolar method of claim 8, further comprising the step of connecting said current source and said impedance processor simultaneously to said individual conductors.

12. The multiple monopolar method of claim 11, further comprising the step of driving said individual conductors at different frequencies, and discriminating on the basis of frequency between signals appearing on said individual conductors from said monopolar electrodes.

13. A system for use in determining desired heart rate for a patient undergoing cardiac therapy, comprising:

means for receiving heart rate data including multiple samples of the patient'"'"'s heart rate during induced variations thereof at a particular workload;

monopolar impedance-based means for measuring the patient'"'"'s stroke volume during said induced variations in heart rate, said monopolar means including means for measuring impedance between a monopolar electrode positioned in the patient'"'"'s heart and a distant reference electrode; and

means coupled to said receiving means and said monopolar impedance-based means for multiplying said heart rate data by said measured stroke volume to obtain an impedance-based value proportional to the patient'"'"'s cardiac output during said induced variations in heart rate.

14. The system of claim 13, further comprising an implantable pacemaker having means for adjustably controlling the patient'"'"'s heart rate, said pacemaker including telemetry means for transmitting heart rate data to said receiving means.

15. The system of claim 14, further comprising means for analzing the relationship between the impedance-based value proportional to cardiac output and the patient'"'"'s heart rate and identifying therefrom the desired heart rate for the patient at said particular workload as the heart rate beyond which the incremental increase in cardiac output for an incremental increase in heart rate is less than a predetermined value.

16. The system of claim 15 wherein said distant reference electrode is located on said pacemaker.

17. A method of determining desired heart rate for a patient undergoing cardiac therapy, comprising the steps of:

inducing variations in the patient'"'"'s heart rate at a particular workload;

measuring the patient'"'"'s heart rate during said induced variations in heart rate;

measuring the patient'"'"'s stroke volume during said induced variations in heart rate, said step of measuring stroke volume including measuring impedance between a monopolar electrode positioned in the patient'"'"'s heart and a distant reference electrode; and

multiplying measured heart rate by measured stroke volume to obtain an impedance-based value proportional to the patient'"'"'s cardiac output during said induced variations in heart rate.

18. The method of claim 17 wherein said step of measuring the patient'"'"'s heart rate is performed with an implantable pacemaker of the type having telemetry means for transmitting heart rate data transcutaneously, and wherein said inducing step includes varying the rate of said pacemaker while maintaining a fixed workload.

19. The method of claim 18, further comprising the step of analyzing the relationship between the impedance-based value proportional to cardiac output and the patient'"'"'s heart rate and identifying therefrom the desired heart rate for the patient at said particular workload as the heart rate beyond which the incremental increase in cardiac output for an incremental increase in heart rate is less than a predetermined value.

20. The method of claim 19 wherein said distant reference electrode is located on said pacemaker.

21. An impedance-based method of detecting ventricular fibrillation of a heart, comprising the steps:

measuring pulsatile impedance changes between a monopolar electrode disposed within said heart and a reference electrode outside said heart; and

detecting the onset of fibrillation by recognition of a reduction of pulsatile impedance changes in excess of a predetermined amount, and the absence of electrical activity for longer than a predetermined interval of time.

22. The method of claim 21 wherein said measuring step is performed with said monopolar electrode centrally positioned within the right ventricle.

23. The method of claim 22 wherein said detecting step includes recognizing a rate of reduction in excess of a predetermined rate characteristic of said heart.

24. A multiple monopolar system for measuring the stroke volume of a patient'"'"'s heart, comprising:

an intracardiac impedance catheter having a distal end and a proximal end;

a plurality of monopolar electrodes axially spaced along the surface of said distal end of said impedance catheter;

an extracardial reference electrode; and

monopolar means for supplying a drive signal and measuring impedance between each of said monopolar electrodes and said extracardial reference electrode.

25. The multiple monopolar system of claim 24, wherein said monopolar means includes means for obtaining a weighted sum of signals from said monopolar electrodes.

26. A multiple monopolar method of measuring the stroke volume of a patient'"'"'s heart, comprising the steps of:

introducing into the patient'"'"'s heart an impedance catheter having a plurality of monopolar electrodes axially spaced along the surface of one end;

positioning a reference electrode outside the patient'"'"'s heart; and

supplying a drive signal and measuring impedance between each of said monopolar electrodes and said reference electrode outside the patient'"'"'s heart for measuring the stroke volume of said heart.

27. The multiple monopolar method of claim 26, further comprising the step of obtaining a weighted sum of signals from said monopolar electrodes.