Method of preparing adhesive dressings containing a pharmaceutically active ingredient

• US 5,059,189 A
• Filed: 09/08/1987
• Issued: 10/22/1991
• Est. Priority Date: 09/08/1987
• Status: Expired due to Term

• Current Assignee: E R Squibb & Sons Incorporated
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Fairbrother, John E., Freeman, Frank M., Cilento, Rodolfo D., Frank, Margaret A.
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Prebilic, Paul
• Application Number:
  US07/094,364
• Time in Patent Office: 1,505 Days
• Field of Search: 128/156, 604/304, 604/307, 604/336, 424/448, 424/449, 156/66, 514/887
• US Class Current: 604/307
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: Y10S 602/90 Method of making bandage structure
• CPC Class Codes: Y10T 428/1452 Polymer derived only from ethylenically unsaturated monomer

Abstract

A dressing comprising a flexible backing member and a pressure sensitive adhesive layer. The adhesive layer comprises one or more polyisobutylenes, elastomers, and one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents. A dispersion of the active ingredient in a medium compatible with the adhesive layer is laminated to the skin contacting surface.

Claims

1. A method of preparing an adhesive dressing containing an pharmaceutically active ingredient comprising:

a) forming a pressure sensitive adhesive mass comprising;

i) one or more low molecular weight polyisobutylenes,

ii) one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, and

iii) various optical ingredients;

b) blending said pressure sensitive adhesive mass from step (a) until homogeneous;

c) layering said blended adhesive mass from step (b) onto a first release coated surface and flattening said mass to form an adhesive layer of desired thickness having a skin contacting surface and an adjacent strata;

d) laminating a flexible backing member to the exposed surface of said adhesive layer from step (c);

e) dispersing a pharmaceutically active ingredient into a mineral oil or thickened mineral oil medium which itself is not an adhesive but is compatible with the composition of said skin contacting adhesion layer;

f) coating or casting said dispersion from step (e) as a uniform layer onto a second release paper; and

g) removing said first release coated surface from said adhesive layer in step (d) and laminating said coated or cast-on second release paper from step (f) to said adhesive layer so that said dispersion of pharmaceutically active ingredient contacts the now exposed surface of said adhesive layer and is absorbed therein to give an adhesive dressing wherein said pharmaceutically active ingredient is present at both said skin contacting surface and said adjacent strata of said adhesive layer.

2. The process of claim 1 wherein said pressure sensitive adhesive means in step (a) comprises from about 15% to about 50% by weight of one or more low molecular weight polyisobutylenes, from about 20% to about 70% by weight of one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, up to about 25% by weight of mineral oil, and up to about 20% by weight of tackifiers.

3. The process of claim 2 wherein said moisture absorbing, moisture transmitting, water soluble agents are selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, xanthan gum, mixed sodium/calcium salts of alginic acid, and carrageenan and said moisture absorbing, moisture transmitting water swellable agents are selected from the group consisting of a water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch acrylonitrile graft copolymers, and water insoluble cross-linked dextran.

10. The process of claim 1 wherein said pharmaceutically active ingredient is a topically active anti-inflammatory agent.

11. The process of claim 10 wherein said anti-inflammatory agent is triamcinolone acetonide and said dispersing medium is thickened mineral oil.

12. The process of claim 3 wherein said flexible backing member is selected from the group consisting of polymeric films, woven and nonwoven fabrics, and polymeric foams.

4. A method of preparing an adhesive dressing containing a pharmaceutically active ingredient comprising:

a) forming a pressure sensitive adhesive mass comprising;

i) one or more low molecular weight polyisobutylenes and one or more elastomers,

ii) one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, and

iii) various optical ingredients;

b) blending said pressure sensitive adhesive mass from step (a) until homogeneous;

c) layering said blended adhesive mass from step (b) onto a first release coated surface and flattening said mass to form an adhesive layer of desired thickness having a skin contacting adhesive surface and an adjacent strata;

d) laminating a flexible backing member to the exposed surface of said adhesive layer from step (c);

e) dispersing a pharmaceutically active ingredient into a mineral oil or thickened mineral oil medium which itself is not an adhesive but is compatible with the composition of said skin contacting adhesive layer;

f) coating or casting said dispersion from step (e) as a uniform layer onto a second release paper; and

g) removing said first release coated surface from said adhesive layer in step (d) and laminating said coated or cast-on second release paper from step (f) to said adhesive layer so that said dispersion of pharmaceutically active ingredient contacts the now exposed surface of said adhesive layer and is absorbed therein to give an adhesive dressing wherein said pharmaceutically active ingredient is present at both said skin contacting surface and said adjacent strata of said adhesive layer.

5. The process of claim 4 wherein said pharmaceutically active ingredient is a topically active anti-inflammatory agent.

6. The process of claim 5 wherein said anti-inflammatory agent is triamcinolone acetonide and said dispersing medium is thickened mineral oil.

7. The process of claim 5 wherein said skin contacting adhesive layer prior to incorporation of the pharmaceutically active ingredient comprises from about 15% to about 50% by weight of blends of one or more low molecular weight polyisobutylenes and one or more elastomers, from about 30% to about 70% by weight of one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents, up to about 25% by weight of mineral oil, and up to about 20% by weight of tackifiers.

8. The process of claim 7 wherein said elastomer is selected from the group consisting of butyl rubber, medium and high molecular weight polyisobutylenes, and styrene radial or block copolymers, and said moisture absorbing, moisture transmitting, water soluble agents are selected from the group consisting of sodium carboxymethylcellulose, calcium carboxymethylcellulose, pectin, gelatin, guar gum, locust bean gum, gum karaya, xanthan gum, mixed sodium/calcium salts of alginic acid, and carrageenan and said moisture absorbing, moisture transmitting water swellable agents are selected from the group consisting of a water insoluble cross-linked sodium carboxymethylcellulose, water insoluble starch-acrylonitrile graft copolymers, and water insoluble cross-linked dextran.

9. The process of claim 8 wherein said flexible backing member is selected from the group consisting of polymeric films, woven and nonwoven fabrics, and polymeric foams.