Absorbable vascular stent

• US 5,059,211 A
• Filed: 06/25/1987
• Issued: 10/22/1991
• Est. Priority Date: 06/25/1987
• Status: Expired due to Term

• Current Assignee: Duke University
• Original Assignee: Duke University
• Inventors: Klopovic, Zemaida P., Stack, Richard S.
• Primary Examiner(s): Thaler, Michael H.
• Application Number:
  US07/066,345
• Time in Patent Office: 1,580 Days
• Field of Search: 128/343, 128/334 R, 623/1, 606/151, 606/153-156, 606/191, 606/198, 606/108
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body

Abstract

An absorbable stent for placement at the locus of a stenotic lesion which is flexible and compliance for safe and effective delivery to the cite of a coronary obstruction, for example, and so as to avoid arterial rupture or aneurysm formation while under continuous stress of a beating heart. The stent is expandable from a reduced diameter configuration, which facilitates delivery to the cite of a targeted arterial obstruction, to an expanded configuration when disposed within the targeted area. The stent can be carried to the cite to be treated and expanded to its supporting diameter on any suitable expandable catheter such as a mechanically expandable catheter or a catheter having an inflatable balloon. The stent is formed so as to have a wall with pores and/or holes to facilitate tissue ingrowth and encapsulation of the stent. The stent will subsequently be bioabsorbed to minimize the likelihood of embolization of the dissolved material.

Claims

1. A vascular stent comprising:

a tubular main body portion having a first open end and a second open end and a lumen extending therethrough, said main body portion being sized for transluminal placement within a coronary artery, said main body portion comprising a sheet of a bioabsorbable material having at least one of holes and pores defined therein for tissue ingrowth which has been rolled into a cylindrical configuration;

said main body portion being expandable from a first reduced diameter allowing intravascular transport to a stenotic portion of a coronary artery to a second expanded diameter at said stenotic portion so as to engage and support the interior wall of the coronary artery in which it is disposed against collapse and restenosis, one longitudinal edge of said sheet including a means for receiving a second longitudinal end of said sheet so as to facilitate rolling of the sheet of material and maintaining same at a predetermined diameter prior to expansion thereof.

2. A vascular stent as in claim 1, in combination with a catheter assembly having a first end adapted to remain exterior to the vascular system and a second end adapted to be inserted into the coronary artery, said second end having an expandable end portion for carrying said main body portion into the coronary artery and for expanding said main body portion from said first reduced diameter to said second expanded diameter within a targeted portion of the coronary artery.

3. The combination of claim 2, further comprising means for mechanically expanding said catheter assembly second end by rotation of a knob provided on said catheter assembly first end.

4. The combination of claim 2, wherein said catheter assembly second end includes an inflatable balloon so as to provide said expansible end portion, whereby the main body portion can be expanded in diameter by inflating the balloon.

5. A method of preventing occlusion and restenosis after transluminal angioplasty comprising:

providing a catheter assembly having an expandable distal end portion;

mounting an expandable vascular stent on said expansible distal end portion of said catheter assembly, said vascular stent including a tubular main body portion having a first open end and a second open end and a lumen extending therethrough, said main body portion being sized for transluminal placement within a coronary artery, said main body portion comprising a sheet of a bioabsorbable material having at least one of holes and pores defined therein for tissue ingrowth which has been rolled into a cylindrical configuration;

said main body portion being expandable from a first reduced diameter allowing intravascular transport to a stenotic portion of a coronary artery to a second expanded diameter at said stenotic portion so as to engage and support the interior wall of the coronary artery in which it is disposed against collapse and restenosis, one longitudinal edge of said sheet including a means for receiving a second longitudinal end of said sheet so as to facilitate rolling of the sheet of material and maintaining same at a predetermined diameter prior to expansion thereof;

inserting said catheter assembly distal end into a coronary artery;

guiding said distal end to a targeted portion of a coronary artery;

expanding said expandable portion so as to expand said vascular stent so as to engage, expand, and support the interior walls of the coronary artery;

reducing the diameter of said distal end portion so as to leave said vascular stent in engagement with and supporting the coronary artery; and

removing the distal end portion of the catheter assembly from the coronary artery.

6. The method as in claim 5, wherein said step of providing a catheter assembly comprises providing a catheter assembly having an inflatable balloon on the distal end thereof.

7. A method as in claim 5, wherein said step of providing a catheter assembly comprises providing a catheter asembly having a mechanically expandable distal end portion.