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Dry reagent for blood coagulation tests

  • US 5,059,525 A
  • Filed: 05/29/1990
  • Issued: 10/22/1991
  • Est. Priority Date: 11/19/1984
  • Status: Expired due to Fees
First Claim
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1. Test strip useful in carrying out a Quick Test, a partial prothromboplastin time test, or in an analysis of one of prothrombin, Factor VII, Factor VIII, Factor IX and Factor X, comprising:

  • (i) a carrier material containing (ii) a protease which reacts with prothrombin, Factor VII, Factor VIII, Factor IX or Factor X to yield an activated protease;

    (iii) a chromophoric protease substrate cleavable by said activated protease in a reaction which does not change the course of the intrinsic or extrinsic coagulation cascade system of blood in the presence of said carrier material, (iv) a buffer, and (v) at least one additional member of the intrinsic or extrinsic coagulation cascade system, wherein said protease reacts with prothrombin, Factor VII, Factor VIII, Factor IX or Factor X in a reaction which is part of the intrinsic or extrinsic coagulation cascade system wherein (ii), (v) are dried on said carrier material.

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