Amino-esters of dihydropyridines useful for improving circulation in patients

• US 5,063,239 A
• Filed: 05/08/1990
• Issued: 11/05/1991
• Est. Priority Date: 03/08/1986
• Status: Expired due to Fees

• Current Assignee: Bayer AG
• Original Assignee: Bayer AG
• Inventors: Stegelmeier, Hartmut, Knorr, Andreas, Kazda, Stanislav, Schwenner, Eckhard
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US07/520,419
• Time in Patent Office: 546 Days
• Field of Search: 546/319, 546/321, 546/270, 514/356, 514/358, 514/357
• US Class Current: 514/357
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 211/90 Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/14 containing three or more hetero rings
• CPC Class Codes: C07D 455/06 containing benzo [a] quinolizine ring systems

Abstract

Circulation active compounds of the formula ##STR1## in which R¹ is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,

R² is optionally substituted alkyl or other radical

R³ and R⁵ are hydrogen, methyl or other radicals,

R⁴ is hydrogen or optionally substituted alkyl,

X is from 2 to 15, and

R⁶ is ##STR2## and physiologically acceptable salts thereof.

Claims

1. An aminoalkyl ester of a dihydropyridinedicarboxylic acid of the formula ##STR45## in which R¹ is phenyl, the phenyl ring being optionally substituted by 1 or 2 identical or different substituents from the group consisting of chlorine, trifluoromethyl, nitro and cyano,

R² is a straight-chain or branched hydrocarbon radical which has up to 7 carbon atoms and is optionally interrupted in the chain by an oxygen atom and said hydrocarbon radical is optionally substituted by fluorine and cyano,

X is a number from 2 to 6, and

R⁶ represents a radical of the formula ##STR46## wherein R⁷ represents hydrogen or methoxy and

R⁸ represents hydrogen, or represents straight-chain or branched C₁ -C₆ -alkyl, or represents the group of the formula ##STR47## or a physiologically acceptable salt thereof.

2. A circulation-active composition comprising a circulation-active effective amount of a compound or salt according to claim 1 and a physiologically acceptable diluent.

3. A unit dose of a composition according to claim 2 in the form of a tablet, capsule or ampule.

4. A method of improving the circulation of a patient in need thereof which comprises administering to such patient a circulation-active effective amount of a compound or salt according to claim 2.