Nonirritating teat dip and method

• US 5,063,249 A
• Filed: 10/23/1989
• Issued: 11/05/1991
• Est. Priority Date: 07/29/1985
• Status: Expired due to Fees

• Current Assignee: 3M Company
• Original Assignee: 3M Company
• Inventors: Andrews, Jeffrey F.
• Primary Examiner(s): Reamer, James H.
• Application Number:
  US07/426,501
• Time in Patent Office: 743 Days
• Field of Search: 514/673
• US Class Current: 514/673
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 33/04 Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
• CPC Class Codes: A01N 37/44 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 9/0041 Mammary glands, e.g. breasts, udder; Intramammary administration

Abstract

A nonirritating germicidal animal test dip comprising certain dodecylaminolkylamine derivatives, an emollient and a film-forming ingredient. A method for controlling mastitis in dairy cows is also described.

Claims

1. A germicidal animal teat dip concentrate comprising, as a substantially stable homogeneous mixture, a germicide selected from the group consisting of 3-(n-dodecylamino)propylamine, a pharmaceutically acceptable acid-addition salt of 3-(n-dodecylamino)-propylamine, 2-[2-(n-dodecylamino)ethylamino]ethylamine, and a pharmaceutically acceptable acid-addition salt of 2-[2-(n-dodecylamino)ethylamino]ethylamine;

as an emollient a polyethylene glycol methyl glucoside;

a film-forming ingredient; and

water, wherein the total amount of all germicide or germicides present in said concentrate is about 0.25 to 2.5 percent based on the total weight of said teat dip concentrate.

2. A teat dip concentrate according to claim 1, further comprising N-[3-(n-dodecylamino)propyl]glycine or a pharmaceutically acceptable acid-addition salt thereof.

3. A teat dip concentrate according to claim 1, wherein said dip concentrate comprises 3-(n-dodecylamino)propylamine in an amount of about 0.2 to 1.8 percent based on the total weight of said teat dip concentrate, and 2-[2-(n-dodecylamino)ethylamino]ethylamine or the hydrochloride salt thereof in an amount of about 0.05 to 0.7 percent based on the total weight of said teat dip concentrate.

4. A teat dip concentrate according to claim 1, wherein a dye is included.

5. A teat dip concentrate according to claim 1, wherein an antifoaming agent is included.

6. A teat dip concentrate according to claim 4, wherein an antifoaming agent is included.

19. A teat dip concentrate according to claim 1, wherein said dip is substantially free of ethylenediaminetetraacetic acid.

7. A germicidal, substantially nonirritating animal teat dip prepared from a concentrate by the addition of water and comprising, as a substantially stable homogeneous mixture, a germicidally effective amount of a germicide selected from the group consisting of 3-(n-dodecylamino)propylamine, a pharmaceutically acceptable acid-addition salt of 3-(n-dodecylamino)propylamine, 2-[2-(n-dodecylamino)ethylamino]ethylamine, and a pharmaceutically acceptable acid-addition salt of 2-[2-(n-dodecylamino)ethylamino]ethylamine;

as an emollient a polyethylene glycol methyl glucoside;

a film-forming ingredient; and

water, said water being present in an amount of at least about 90% by weight based on the total weight of said teat dip, wherein the total amount of all germicide or germicides present in said concentrate from which said teat dip is prepared is about 0.25 to 2.5 percent based on the total weight of said teat dip concentrate.

8. A teat dip according to claim 7, further comprising N-[3-(n-dodecylamino)propyl]glycine or a pharmaceutically acceptable acid-addition salt thereof.

9. A teat dip according to claim 7, wherein said teat dip comprises 3-(n-dodecylamino)propylamine or the hydrochloride salt thereof in an amount of about 0.025 to 0.25 percent based on the total weight of said teat dip;

and 2-[2-(n-dodecylamino)ethylamino]ethylamine or the hydrochloride salt thereof in an amount of about 0.005 to 0.10 percent based on the total weight of said teat dip.

10. A teat dip according to claim 7, wherein a dye is included.

11. A teat dip according to claim 7, wherein an antifoaming agent is included.

12. A teat dip according to claim 10, wherein an antifoaming agent is included.

13. A method for controlling bovine mastitis comprising immersing the teats of a cow in a substantially nonirritating teat dip prepared from a concentrate by the addition of water and comprising, as a substantially stable homogeneous mixture, a germicidally effective amount of a germicide selected from the group consisting of 3-(n-dodecylamino)propylamine, a pharmaceutically acceptable acid-addition salt of 3-(n-dodecylamino)propylamine, 2-[2-(n-dodecylamino)ethylamino]ethylamine, and a pharmaceutically acceptable acid-addition salt of 2-[2-(n-dodecylamino)ethylamino]ethylamine;

as an emollient a polyethylene glycol methyl glucoside a film-forming ingredient; and

water, wherein the total amount of all germicide or germicides present in said concentrate from which said teat dip is prepared is about 0.25 to 2.5 percent based on the total weight of said teat dip concentrate.

14. A method according to claim 13, wherein said teat dip further comprises N-[3-(n-dodecylamino)propyl]glycine or a pharmaceutically acceptable acid-addition salt thereof.

15. A method according to claim 13, wherein said teat dip further includes a dye.

16. A method according to claim 13, wherein said teat dip further includes an antifoaming agent.

17. A method according to claim 16, wherein said teat dip further includes a dye.

18. A method according to claim 13, wherein said teat dip comprises 3-(n-dodecylamino)propylamine or the hydrochloride salt thereof in an amount of about 0.025 to 0.25 percent based on the total weight of said teat dip, and 2-[2-(n-dodecylamino)ethylamino]ethylamine or the hydrochloride salt thereof in an amount of about 0.005 to 0.10 percent based on the total weight of said teat dip.