Ultrasonic air-in-line detector for a medication infusion system

• US 5,064,412 A
• Filed: 09/05/1989
• Issued: 11/12/1991
• Est. Priority Date: 09/05/1989
• Status: Expired due to Term

• Current Assignee: Carefusion 303 Incorporated (Becton, Dickinson & Co)
• Original Assignee: Pacesetter Infusion, Ltd. (Siemens AG)
• Inventors: Henke, James L., Koenig, Paul A.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Lacyk, John P.
• Application Number:
  US07/403,512
• Time in Patent Office: 798 Days
• Field of Search: 604/65-67, 604/122, 604/123, 128/DIG. 12, 128/DIG. 13
• US Class Current: 604/65
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: G01N 29/032 by measuring attenuation of acoustic waves
• CPC Class Codes: G01N 29/4454 Signal recognition, e.g. specific values or portions, signal events, signatures
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

An ultrasonic air-in-line detection system for use in detecting air bubbles in the fluid line of a disposable cassette mounted on a main pump unit is disclosed which can accurately detect air bubbles in any type of fluid, whether clear or opaque. The system uses a windowing technique to determine when a threshold amount of air bubbles in a predetermined volume of material pumped occurs, with the alarm being sounded only when this threshold amount of air bubbles is present in the window volume. The system of the present invention thus avoids so-called nuisance alarms due to the presence of small isolated air bubbles in the fluid due to the fluid pumped not having been degassed.

Claims

1. A system for detecting the presence of a significant amount of air in fluid passing through a fluid passageway, comprising:

ultrasonic sensor means disposed adjacent said fluid passageway for providing an air-in-line output signal indicative of whether there is presently air or fluid in said fluid passageway at the location monitored by said ultrasonic sensor means;

means for monitoring the volume pumped through said fluid passageway, said monitoring means providing a volume output signal indicative of the volume pumped;

means, responsive to said air-in-line output signal and said volume output signal, for calculating the volume of air contained in the last predetermined volume pumped through said fluid passageway, said calculating means providing as an output the volume of air contained in the last predetermined volume pumped; and

means for providing an alarm signal if the output from said calculating means is equal to or greater than a second predetermined volume.

2. A system as defined in claim 1, wherein said ultrasonic sensor means comprises:

transmitter means for transmitting an ultrasonic signal applied to said fluid passageway;

receiver means for detecting whether said ultrasonic signal passes through said fluid passageway and for providing said air-in-line signal indicating the current presence of fluid or air in said fluid passageway at the location monitored by said ultrasonic sensor means.

3. A system as defined in claim 2, wherein said transmitter means comprises:

a first ultrasonic transducer located on one side of said fluid passageway; and

means for driving said first ultrasonic transducer to generate ultrasonic vibrations which are transmitted to said one side of said fluid passageway; and

said receiver means comprises;

a second ultrasonic transducer located on the other side of said fluid passageway, said ultrasonic vibrations passing through said fluid passageway and being received by said second ultrasonic transducer when there is fluid in said fluid passageway, said ultrasonic vibrations substantially not passing through said fluid passageway and not being received by said second ultrasonic transducer when there is an air bubble in said fluid passageway; and

means for detecting the ultrasonic vibrations received by said second transducer and providing said air-in-line output signal indicative of whether there is presently air or fluid in said fluid passageway between said first and second transducers.

4. A system as defined in claim 3, wherein said first and second ultrasonic transducers have a resonant frequency, said driving means generating an oscillating signal which sweeps from a first frequency to a second frequency, said resonant frequency being between said first and second frequencies.

5. A system as defined in claim 3, wherein said detecting means comprises:

an amplifier for amplifying an electrical signal generated by said second ultrasonic transducer;

a rectifier for rectifying the amplified electrical signal generated by said second ultrasonic transducer;

a first comparator for producing a first comparator output signal when the rectified, amplified electrical signal generated by said second ultrasonic transducer exceeds a first threshold.

6. A system as defined in claim 3, wherein said driving means operates periodically to drive said first ultrasonic transducer to generate ultrasonic vibrations.

7. A system as defined in claim 6, wherein said driving means operates on a one-eighth duty cycle.

8. A system as defined in claim 6, wherein said driving means operates at a frequency sufficiently high to ensure that an air bubble will be detected at even the highest possible rate of fluid flow through said fluid passageway.

9. A system as defined in claim 8, wherein said driving means operates at a frequency of approximately 750 Hz.

10. A system as defined in claim 1, additionally comprising a piston pump for pumping fluid through said fluid passageway and means for driving said pump, said monitoring means comprising:

encoder means for providing position information describing the position of said piston pump; and

means for decoding said position information to determine how much volume has been pumped from a first item of position information to a second item of position information.

11. A system as defined in claim 10, additionally comprising:

means for measuring the pressure in said fluid passageway; and

means for modifying the volume as determined by said decoding means by according to the measured pressure in said fluid passageway to produce said volume output signal.

12. A system as defined in claim 1, additionally comprising:

means for selecting the size of said last predetermined volume pumped from a plurality of selections.

13. A system as defined in claim 1, wherein the size of said last predetermined volume is less than the volume of said fluid passageway from the location monitored by said ultrasonic sensor to a patient.

14. A system as defined in claim 1, wherein the size of said last predetermined volume is between approximately 100 milliliters and 300 milliliters.

15. A system as defined in claim 1, wherein said second predetermined volume is between one-twentieth and one-sixth of the size of said last predetermined volume.

16. A system as defined in claim 15, wherein said second predetermined volume is one-sixth of the size of said last predetermined volume.

17. A system as defined in claim 1, wherein said means for providing an alarm signal provides an audible or visible alarm signal and shuts down the pumping operation through said fluid passageway.

18. A system for detecting the presence of a significant amount of air in fluid passing through a fluid passageway, comprising:

a first ultrasonic transducer located on one side of said fluid passageway;

a second ultrasonic transducer located on the other side of said fluid passageway;

means for driving said first ultrasonic transducer to generate ultrasonic vibrations which are transmitted to said one side of said fluid passageway, said ultrasonic vibrations passing through said fluid passageway and being received by said second ultrasonic transducer when there is fluid in said fluid passageway, said ultrasonic vibrations substantially not passing through said fluid passageway and not being received by said second ultrasonic transducer when there is an air bubble in said fluid passageway;

receiver means for detecting the ultrasonic vibrations received by said second transducer and providing an air-in-line output signal indicative of whether there is presently air or fluid in said fluid passageway between said first and second transducers;

means for monitoring the volume pumped through said fluid passageway, said monitoring means providing a volume output signal indicative of the volume pumped;

means, responsive to said air-in-line output signal and said volume output signal, for calculating the volume of air contained in the last predetermined volume pumped through said fluid passageway, said calculating means providing as an output the volume of air contained in the last predetermined volume pumped; and

means for providing an alarm signal if the output from said calculating means is equal to or greater than a second predetermined volume.

19. A system for detecting the presence of a significant amount of air in fluid passing through a fluid passageway, comprising:

sensor means disposed adjacent said fluid passageway for providing an air-in-line output signal indicative of whether there is presently air or fluid in said fluid passageway at the location monitored by said sensor means;

means for monitoring the volume pumped through said fluid passageway, said monitoring means providing a volume output signal indicative of the volume pumped;

means, responsive to said air-in-line output signal and said volume output signal, for calculating the volume of air contained in the last predetermined volume pumped through said fluid passageway, said calculating means providing as an output the volume of air contained in the last predetermined volume pumped; and

means for providing an alarm signal if the output from said calculating means is equal to or greater than a second predetermined volume.

20. A method of detecting the presence of a significant amount of air in fluid passing through a fluid passageway, comprising:

providing an air-in-line output signal indicative of whether there is presently air or fluid in said fluid passageway at a particular location with an ultrasonic sensor means disposed adjacent said fluid passageway at said particular location;

monitoring the volume pumped through said fluid passageway and providing a volume output signal indicative of the volume pumped;

calculating, from said air-in-line output signal and said volume output signal, the volume of air contained in the last predetermined volume pumped through said fluid passageway and providing as an output the volume of air contained in the last predetermined volume pumped; and

providing an alarm signal if the output from said calculating means is equal to or greater than a second predetermined volume.