Hydrophilic foam compositions

• US 5,064,653 A
• Filed: 03/29/1988
• Issued: 11/12/1991
• Est. Priority Date: 03/29/1988
• Status: Expired due to Term

• Current Assignee: Ferris Pharmaceuticals Incorporated
• Original Assignee: Ferris Manufacturing Company
• Inventors: Sessions, Robert W., Carr, Roy D.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, William E.
• Application Number:
  US07/175,036
• Time in Patent Office: 1,323 Days
• Field of Search: 523/105, 523/111, 521/109.1, 521/905, 424/445, 424/404
• US Class Current: 424/445
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/530481 having superabsorbent materials, i.e. highly absorbent polymer gel materials
• CPC Class Codes: A61F 2013/530802 characterized by the foam or sponge other than superabsorbent A61F2013/530649 takes precedence
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 26/0019 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/282 Alkanols, cycloalkanols or arylalkanols including terpenealcohols
• CPC Class Codes: C08G 18/302 Water
• CPC Class Codes: C08G 18/3206 aliphatic
• CPC Class Codes: C08G 18/48 Polyethers
• CPC Class Codes: C08G 2101/00 Manufacture of cellular products
• CPC Class Codes: C08G 2110/0066 ≥ 150kg/m3
• CPC Class Codes: C08G 2110/0083 prepared using water as the sole blowing agent
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A hydrophilic foam composition comprising the in situ reaction product of an isocyanate-capped polyether prepolymer, a hydrophilic agent capable of absorbing water, an adjuvant comprising an alcohol, a wetting agent, and water.

Claims

1. A hydrophilic foam composition comprising the in situ reaction product of:

a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

2. The hydrophilic foam composition of claim 1 wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g and mixtures thereof.

3. The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 20 wt. % to about 60 wt. % of the total reactant composition.

4. The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 45 to about 50 wt. % of the total reactant composition.

5. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said polymer.

6. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 100 ml of water per gram of said polymer.

7. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 150 ml of water per gram of said polymer.

8. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof.

9. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.

10. The hydrophilic foam composition of claim 8 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.

11. The hydrophilic foam composition of claim 9 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.

12. The hydrophilic foam composition of claim 10 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.

13. The hydrophilic foam composition of claim 1 wherein said alcohol is a monol.

14. The hydrophilic foam composition of claim 1 wherein said alcohol is a diol.

15. The hydrophilic foam composition of claim 1 wherein said alcohol is a polyhydric alcohol.

16. The hydrophilic foam composition of claim 15 wherein said polyhydric alcohol has a molecular weight of less than about 1000.

17. The hydrophilic foam composition of claim 1 wherein said alcohol is a member selected from the group consisting of isopropyl alcohol, ethanol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof.

18. The hydrophilic foam composition of claim 10 wherein said alcohol is glycerin.

19. The hydrophilic foam composition of claim 1 wherein said alcohol is present in an amount of from about 5% to about 30% by weight of the reactant composition.

20. The hydrophilic foam composition of claim 1 wherein said wetting agent is a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof.

21. The hydrophilic foam composition of claim 20 wherein said wetting agent is present in an amount of from about 1% to about 10% by weight of said reactant composition.

22. The hydrophilic foam composition of claim 1 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:

1 to about 20;

10 and the ratio of prepolymer to adjuvant is in the range of from about 20;

2 to about 20;

30.

23. A hydrophilic foam composition comprising the in situ reaction product of :

a) an isocyanate-capped polyether prepolymer, wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g, b) a hydrophilic agent capable of absorbing water, said hydrophilic agent being a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof;

c) an adjuvant comprising an alcohol, said adjuvant being a member selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4- butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof;

said reactant composition (d) including a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof, and e) water, said water being a member selected from the group consisting of deionized water, distilled water and normal saline.

24. The hydrophilic foam composition of claim 23 wherein said prepolymer is an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625;

said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt);

said adjuvant comprises glycerine, and said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.

40. The hydrophilic foam composition of claim 23 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:

1 to about 20;

10 and the ratio of prepolymer to adjuvant is in the range of from about 20;

2 about 20;

30.

25. A wound dressing comprising the in situ reaction product of:

a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

29. The wound dressing of claim 25 wherein said hydrophilic agent comprises an additive selected from the group consisting of methylcellulose, guar gum, pectin, karaya gum, chitosan, agar, acacia powder, carrageenan, gelatin, and mixtures thereof.

30. The wound dressing of claim 25 wherein said adjuvant comprises a therapeutic agent.

31. The wound dressing of claim 25 wherein said adjuvant comprises a medicament.

32. The wound dressing of claim 25 wherein said adjuvant comprises a cosmetic.

33. The wound dressing of claim 30 wherein said therapeutic agent is selected from the group consisting of soluble collagen, hydrolyzed collagen, collagen amino acids salt free, hydrolyzed animal protein and hyaluronic acid, an ointment including methyl salicylate and menthol and hydrocortisone acetate.

34. The wound dressing of claim 32 wherein said cosmetic is selected from the group consisting of collagen complex, liposomes, bath oil, a lotion, a cream, a herbal and aloe lotion, an ointment and tretinoin cream.

37. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 25.

26. A wound dressing composition comprising the in situ reaction product of:

a) an isocyanate-capped polyether prepolymer selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 7.5 meq/g, b) a hydrophilic agent capable of absorbing water selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof, c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof, d) a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propyleneoxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids, and mixtures thereof, and e) water selected from the group consisting of deionized water, distilled water, and normal saline, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

27. A wound dressing comprising a hydrophilic foam composition comprising the in situ reaction product of

(a) an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of from about 0.5 meq/g to about 3 meq/g;

(b) a hydrophilic agent capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said agent, and wherein said hydrophilic agent comprises a hydrophilic material which is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof;

(c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol sorbitol, and mixtures thereof;

(d) a wetting agent comprising a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof; and

(e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released from said foam composition in the presence of the external liquid.

28. The wound dressing of claim 27 wherein said water is selected from the group consisting of deionized water, distilled water and normal saline.

35. The wound dressing of claim 27 wherein said isocyanate-capped polyether prepolymer has an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625;

said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt), said adjuvant comprises glycerin, said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.

36. The wound dressing of claim 35 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer o hydrophilic agent is in the range of from about 20:

1 to about 20;

10 and the ratio of prepolymer to adjuvant is in the range of from about 20;

2 to about 20;

30.

38. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 27.

39. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 35.