Hydrophilic foam compositions

• US 5,065,752 A
• Filed: 05/28/1991
• Issued: 11/19/1991
• Est. Priority Date: 03/29/1988
• Status: Expired due to Term

• Current Assignee: Ferris Pharmaceuticals Incorporated
• Original Assignee: Ferris Manufacturing Company
• Inventors: Sessions, Robert W., Carr, Roy D.
• Primary Examiner(s): Foelak, Morton
• Application Number:
  US07/705,938
• Time in Patent Office: 175 Days
• Field of Search: 128/156, 428/304.4, 428/317.1
• US Class Current: 602/46
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/530481 having superabsorbent materials, i.e. highly absorbent polymer gel materials
• CPC Class Codes: A61F 2013/530802 characterized by the foam or sponge other than superabsorbent A61F2013/530649 takes precedence
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/046 Aerosols; Foams
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 26/0019 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/282 Alkanols, cycloalkanols or arylalkanols including terpenealcohols
• CPC Class Codes: C08G 18/302 Water
• CPC Class Codes: C08G 18/3206 aliphatic
• CPC Class Codes: C08G 18/48 Polyethers
• CPC Class Codes: C08G 2101/00 Manufacture of cellular products
• CPC Class Codes: C08G 2110/0066 ≥ 150kg/m3
• CPC Class Codes: C08G 2110/0083 prepared using water as the sole blowing agent
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: Y10T 428/249953 : Composite having voids in a component [e.g., porous, cellular, etc.]
• CPC Class Codes: Y10T 428/249982 : With component specified as adhesive or bonding agent

Abstract

A hydrophilic foam composition comprising the in situ reaction product of an isocyanate-capped polyether prepolymer, a hydrophilic agent capable of absorbing water, an adjuvant comprising an alcohol, a wetting agent, and water.

Claims

1. A composite for use in a wound dressing comprising a substrate, a medically acceptable adhesive deposited on said substrate and a hydrophilic foam composition carried by said adhesive, said composition comprising the in situ reaction product of:

(a) an isocyanate-capped polyether prepolymer,

(b) a polymeric hydrophilic agent capable of absorbing water,

(c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols,

(d) a wetting agent, and

(e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.

5. A method for treating a wound comprising applying to the wound a composite as claimed in claim 1.

2. A composite for use in a wound dressing comprising a substrate, a medically acceptable adhesive deposited on said substrate and a hydrophilic foam composition, said composition comprising the in situ reaction product of:

(a) an isocyanate-capped polyether prepolymer, wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meg/g to about 3.0 meg/g,

(b) a hydrophilic agent capable of absorbing water, said hydrophilic agent being a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof;

(c) an adjuvant comprising an alcohol, said adjuvant being a member selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof;

said reactant composition including;

(d) a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof, and

(e) water, said water being a member selected from the group consisting of deionized water, distilled water and normal saline.

6. A method for treating a wound comprising applying to the wound a composite as claimed in claim 2.

3. A method for making a composite for use in a wound dressing comprising:

providing a substrate,

applying a medically acceptable adhesive to said substrate,

applying a reactant composition to said adhesive, said reactant composition comprising an isocyanate-capped polyether prepolymer, a polymeric hydrophilic agent capable of absorbing water, an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, a wetting agent and water, and

curing said reactant composition while it is in contact with said adhesive.

7. A composite made by the method of claim 3.

9. A method for treating a wound comprising applying to the wound a composite as claimed in claim 7.

4. A method for making a composite for use in a wound dressing comprising:

providing a substrate,

applying a medically acceptable adhesive to said substrate,

applying a reactant composition to said adhesive, said reactant composition comprising

(a) an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of from about 0.5 meq/g to about 3 meq/g;

(b) a hydrophilic agent capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said agent, and wherein said hydrophilic agent comprises a hydrophilic material which is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof;

(c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerin, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol sorbitol, and mixtures thereof;

(d) a wetting agent comprising a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof; and

(e) water,

curing said reactant composition while it is in contact with said adhesive to form a foam composition that is unreleasably attached to said adhesive, said foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released from said foam composition in the presence of the external liquid.

8. A composite made by the method of claim 4.

10. A method for treating a wound comprising applying to the wound a composite as claimed in claim 8.