Antisudoral composition comprising dibasic aluminium salts of acylated amino acids

• US 5,066,487 A
• Filed: 09/12/1989
• Issued: 11/19/1991
• Est. Priority Date: 09/14/1988
• Status: Expired due to Fees

• Current Assignee: Eliane Lauzanne-Morelle, Jean V. Morelle
• Original Assignee: Rhone-Poulenc Chimie
• Inventors: Morelle, Jean V., Lauzanne-Morelle, Eliane
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Kulkosky, Peter F.
• Application Number:
  US07/406,435
• Time in Patent Office: 798 Days
• Field of Search: 424/68, 424/81, 424/78, 556/181
• US Class Current: 424/68
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00

Abstract

Dibasic aluminium salts of acylated amino acids having the formula ##STR1## (R═C₅ --C₁₀ hydrocarbon, R'"'"' is the main chain of the illustrated α-amino-acid) have antisudoral properties. R'"'"' may be such that the α-aminoacid is singular, e.g. lysine, glycine or aspartic acid, or a mixture, e.g. a hydrolysate of a protein such as collagen, keratin or casein. R may be saturated, e.g. pentyl, heptyl or nonyl, or unsaturated, e.g. dec-9-enyl. Antisudoral compositions containing these salts are described.

Claims

1. An antisudoral composition containing a dibasic aluminium salt of an acylated amino acid having the formula ##STR5## wherein R represents a hydrocarbon chain having from 5 to 10 carbon atoms and R'"'"' represents the main chain of the illustrated α

-amino acid or a mixture of such salts, together with a diluent or carrier.

13. An antisudoral composition according to claim 1 in which R represents a radical selected from the group consisting of pentyl, heptyl, nonyl and dec-9-enyl.

14. An antisudoral composition according to claim 1 in which R'"'"' is such that the α

-amino acid is selected from the group consisting of lysine, glycine and asparatic acid.

15. An antisudoral composition according to claim 13 in which R'"'"' is such that the α

-amino acid is selected from the group consisting of lysine, glycine and aspartic acid.

16. An antisudoral composition according to claim 1 in which R'"'"' is such that the α

amino acid is a protein hydrolysis mixture.

17. An antisudoral composition according to claim 16 in which the protein is selected from the group consisting of collagen, keratin and casein.

18. An antisudoral composition according to claim 13 in which R'"'"' is such that the α

-amino acid is a protein hydrolysis mixture.

19. An antisudoral composition according to claim 18 in which the protein is selected from the group consisting of collagen, keratin and casein.

3. An antisudoral composition comprising

4. An antisudoral composition comprising

5. An antisudoral composition comprising

6. An antisudoral composition comprising

7. An antisudoral composition comprising

8. An antisudoral composition comprising

9. An antisudoral composition comprising

10. An antisudoral composition comprising

View Dependent Claims (2, 12)

2. An antisudoral composition according to claim 10 in which the dibasic aluminium salt of the acylated amino acid, or the mixture of such salts, comprises from 5 to 10% of the composition.

12. A method for the treatment of sudoration, the method comprising topically applying a composition according to claim 10 to the patient.

11. An antisudoral composition comprising