Apparatus for filling self-sealing tubes

• US 5,067,532 A
• Filed: 02/20/1990
• Issued: 11/26/1991
• Est. Priority Date: 09/22/1988
• Status: Expired due to Fees

• Current Assignee: Eolas - The Irish Science and Technology Agency A Body Corporate Established By Stature of Ireland
• Original Assignee: Eolas - The Irish Science and Technology Agency A Body Corporate Established By Stature of Ireland
• Inventors: Lang, John, Garvey, Cormac
• Primary Examiner(s): Cusick, Ernest G.
• Application Number:
  US07/481,185
• Time in Patent Office: 644 Days
• Field of Search: 141/1, 141/329, 141/330, 141/130, 141/165, 141/168, 141/269, 141/270, 141/284, 141/369, 141/370, 141/372, 141/164, 141/171, 141/25-27, 141/97, 141/82, 269/25, 269/268, 269/270, 422/104
• US Class Current: 141/329
• CPC Class Codes: B01L 3/0293 for liquids
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like
• CPC Class Codes: G01N 1/18 with provision for splitting samples into portions G01N1/12, G01N1/14 take precedence; fraction-collection apparatus for chromatography B01D15/08

Abstract

An apparatus includes a conveyor system for conveying tubes, having respective self-sealing closure members, sequentially to a station whereupon the conveyor system is temporarily halted. At the station, a clamping device having a clamp lowers to prevent movement of the tube. An arm moves in the direction of the tube to enable a hollow needle to penetrate the closure member of the tube. A metering pump enables a predetermined volume of a fluid, preferably liquid agar, to be introduced into the tube. Following release of the needle from the closure member, the conveyor systems moves to enable another tube to arrive at the station.

Claims

1. An apparatus for introducing a fluid into a tube having a self-sealing closure means, said apparatus comprising:

a base;

clamping means having a substantially hemi-tubular construction for releasably clamping the tube against the base at a fluid injecting station and for releasably maintaining the tube in a substantially horizontal position;

injector means including a first hollow injector needle selectively engageable with said closure means;

means for enabling the needle to penetrate the closure means thereby introducing a charge of liquid into the tube and for enabling the needle to be withdrawn from the tube; and

means for raising and lowering the clamping means relative to the tube so that in a first position of use, the clamping means is in engagement with the tube so as to bias the tube gently but firmly downwards against the base and in a second position of use the clamping means is out of engagement with the tube.

2. The apparatus as claimed in claim 1, wherein the hollow injector needle includes a reservoir for the fluid and metering means for pumping the fluid.

3. The apparatus as claimed in claim 2, wherein the metering means includes a peristaltic pump.

4. The apparatus as claimed in claim 2, wherein the fluid is sterile, and the tube, the reservoir and the injector needle for conveying the fluid from the reservoir into the tube provide a sterile pathway for the fluid.

5. The apparatus as claimed in claim 1, wherein the base comprises a conveyor apparatus for enabling a plurality of tubes to be fed sequentially to and from the fluid injecting station, said conveyor apparatus is operatively associated with the clamping means so that when the clamping means is in the first position of use, the conveyor apparatus is stationary.

6. The apparatus as claimed in claim 1, wherein the fluid is liquid agar.

7. The apparatus as claimed in claim 1, further including heating means for maintaining the agar at the temperature of about 50°

C.

8. The apparatus as claimed in claim 1, wherein the tube is an evacuated tube.

9. The apparatus as claimed in claim 1, wherein the tube is a non-evacuated tube.

10. The apparatus as claimed in claim 9, wherein the injector means includes a second hollow needle in a parallel spaced apart relationship relative to the first needle, which second needle enables venting of the tube during fluid introduction into the tube.

11. The apparatus as claimed in claim 1, wherein the fluid is sterile and the tube and the hollow injector needle for conveying the fluid into the tube provide a sterile pathway for the fluid.

12. An apparatus for introducing a fluid into a tube having a self-sealing closure means, said apparatus comprising:

a base;

clamping means for releasably clamping the tube against the base at a fluid injection station;

a first hollow injector needle selectively engageable with said closure means; and

means for enabling the first needle to penetrate the closure means for introducing a charge of fluid into the tube and for enabling the needle to be withdrawn from the tube;

wherein the base comprises a conveyor apparatus for enabling a plurality of tubes to be fed sequentially to and from the station, said conveyor being operatively associated with the clamping means so that when the clamping means is in the first position of use, the conveyor apparatus is stationary.

13. The apparatus as claimed in claim 12, wherein the clamping means is adapted for maintaining the tube in a substantially horizontal position.

14. The apparatus as claimed in claim 12, wherein the clamping means is of substantially hemi-tubular construction and comprises means for raising and lowering the clamp relative to the tube so that in a first position of use, the clamping means is in engagement with the tube so as to bias the tube gently but firmly downwards against the base and in a second position of use the clamping means is out of engagement with the tube.

15. The apparatus as claimed in claim 12, wherein the means for metering comprises a peristaltic pump.

16. The apparatus as claimed in claim 12, wherein the fluid is liquid agar.

17. The apparatus as claimed in claim 16, further including heating means for maintaining the agar at a temperature of about 50°

l C.

18. The apparatus as claimed in claim 12, wherein the tube is evacuated.

19. The apparatus as claimed in claim 12, wherein the tube is non-evacuated.

20. The apparatus as claimed in claim 19, wherein the injector means includes a second hollow needle in a parallel spaced apart relationship relative to the first needle, said second needle enabling venting of the tube during fluid introduction into the tube.

21. The apparatus as claimed in claim 12, and further comprising a reservoir for the fluid.

22. The apparatus as claimed in claim 12, and further comprising means for metering the fluid.

23. The apparatus as claimed in claim 12, wherein the fluid is sterile and the tube and the first needle for conveying the fluid into the tube provide a sterile pathway for the fluid.

24. The apparatus as claimed in claim 21 wherein the fluid is sterile and the tube, the resevoir and the first needle for conveying the fluid from the reservoir into the tube provide a sterile pathway for the fluid.