(2R,3S,4S)-.alpha.-(carboxycyclopropyl)glycine

• US 5,068,412 A
• Filed: 10/17/1989
• Issued: 11/26/1991
• Est. Priority Date: 10/17/1988
• Status: Expired due to Term

• Current Assignee: Suntory Holdings Limited (Kotobuki Realty Co., Ltd.)
• Original Assignee: Suntory Ltd (Kotobuki Realty Co., Ltd.)
• Inventors: Shimamoto, Keiko, Ohfune, Yasufumi, Ishida, Michiko, Shinozaki, Haruhiko
• Primary Examiner(s): Shippen, Michael L.
• Application Number:
  US07/422,796
• Time in Patent Office: 770 Days
• Field of Search: 562/506
• US Class Current: 562/506
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07C 229/48 with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
• CPC Class Codes: C07C 2601/02 with a three-membered ring

Abstract

(2R,3S,4S)-α-(carboxycyclopropyl)glycine of the formula (1) and salts thereof are disclosed. ##STR1## The compound (1) exhibits most potent depolarizing activities among the known NMDA agonists and will be a useful tool to investigate various neuronal functions related to the excitatory amino acid receptors.

Claims

1. (2R,3S,4S)-α

-(carboxycyclopropyl)glycine of the formula (1) or salts thereof selected from the group consisting of ammonium, sodium, potassium and calcium salts. ##STR7##