Cancer treatment

• US 5,069,662 A
• Filed: 10/21/1988
• Issued: 12/03/1991
• Est. Priority Date: 10/21/1988
• Status: Expired due to Term

• Current Assignee: Delcath Systems, Inc.
• Original Assignee: Delcath Systems, Inc.
• Inventors: Bodden, William L.
• Primary Examiner(s): Hafer, Robert A.
• Assistant Examiner(s): Owens, Kerry
• Application Number:
  US07/260,623
• Time in Patent Office: 1,138 Days
• Field of Search: 604/4, 604/5, 604/6, 604/7, 604/8, 604/101, 210/23
• US Class Current: 604/5.01
• CPC Class Codes: A61M 1/3615 Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 2025/0003 having an additional lumen transmitting fluid pressure to the outside for measurement
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/232 Centrifugal pumps
• CPC Class Codes: A61M 60/31 for enhancement of in vivo organ perfusion, e.g. retroperfusion
• CPC Class Codes: A61M 60/36 for specific blood treatment; for specific therapy
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61M 60/554 of blood pressure
• CPC Class Codes: A61M 60/818 Bearings
• CPC Class Codes: A61M 60/833 Occluders for preventing backflow
• CPC Class Codes: A61M 60/849 Disposable parts

Abstract

Perfusing a high concentration of an agent to treat an organ, such as anti-cancer agents through a body organ containing a tumor, without their entering the body'"'"'s general circulation, removing them from the organ with effluent blood and transporting the contaminated blood to an extracorporeal circuit where the blood is treated to remove the contamination, and returning the treated blood to the body. The process prevents toxic levels of the agents from entering the body'"'"'s general circulation while delivering lethal doses of the agents to the tumor. There are described various apparatus for effecting the intra- and extracorporeal treatment of such contaminated blood.

Claims

1. In a process for perfusing a high concentration of an agent through a body organ requiring treatment without contaminating the body'"'"'s general circulation, the improvement comprising:

percutaneously inserting a single catheter having spaced balloons into the inferior vena cava of a body in which an organ is to be treated by perfusing a high concentration of a treating agent, said catheter being moved to a position in which inflation of the spaced balloons isolate effluent blood from the organ from the body'"'"'s general circulation, said catheter having a lumen for removing blood derived from said organ;

inflating the balloons to isolate said effluent blood;

removing from the body through said lumen in said catheter essentially all of the effluent blood from said organ, said effluent blood containing said agent;

treating removed effluent blood to reduce the quantity of treating agent; and

returning the thus treated blood to the body via the superior vena cava, a subclavian vein, a jugular vein or the right atrium.

2. The process of claim 1 wherein the organ is the liver.

3. The process of claim 2 wherein the treating agent is a cancer treating agent.

4. The process of claim 1 wherein said catheter includes a plurality of holes which place blood in the inferior vena cava in fluid flow communication with said lumen.

5. The process of claim 1 wherein said catheter includes a separate lumen for a guidewire and said catheter is inserted by use of a guidewire in said separate lumen.