Crosslinked hydrogel and method for making same
First Claim
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1. A crosslinked hydrogel for use in transcutaneous electrical nerve stimulation and iontophoresis to provide transdermal delivery of an active ingredient comprising:
- (a) an active ingredient selected from the class of lidocainehydrochloride, hydrocortisone, menthol or methyl salicylate;
(b) a crosslinking agent, aluminum acetate in a quantity of about 0.1% to about 0.5% by weight to provide ionic conductivity in said hydrogel;
(c) water;
(d) an emulsifier selected from the class of propyleneglycol, lanolin, stearic acid or ethyl alcohol; and
(e) carboxymethylcellulose in an amount of between 1.1% to 1.7% by weight, wherein said hydrogel is characterized by having an electrical resistance of less than 10,000 ohms per linear centimeter.
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Abstract
A chemically crosslinked hydrogel includes an active ingredient for transdermal transport selected from the group of lidocainehydrochloride, hydrocortisone, menthol, and methyl salicylate and utilizes as a crosslinking agent an aluminum acetate, which is a polyvalent salt, which renders the resulting hydrogel electrically conductive with a resistance of less than 10,000 ohms per linear centimeter.
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Citations
10 Claims
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1. A crosslinked hydrogel for use in transcutaneous electrical nerve stimulation and iontophoresis to provide transdermal delivery of an active ingredient comprising:
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(a) an active ingredient selected from the class of lidocainehydrochloride, hydrocortisone, menthol or methyl salicylate; (b) a crosslinking agent, aluminum acetate in a quantity of about 0.1% to about 0.5% by weight to provide ionic conductivity in said hydrogel; (c) water; (d) an emulsifier selected from the class of propyleneglycol, lanolin, stearic acid or ethyl alcohol; and (e) carboxymethylcellulose in an amount of between 1.1% to 1.7% by weight, wherein said hydrogel is characterized by having an electrical resistance of less than 10,000 ohms per linear centimeter. - View Dependent Claims (2, 3, 4, 5)
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6. A crosslinked hydrogen containing an active ingredient for transdermal medical application comprising:
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(a) water; (b) an active ingredient selected from the class of menthol, methyl salicylate, lidocainehydrochloride or hydrocortisone; (c) aluminum acetate, a crosslinking agent providing ionic conductivity to said hydrogel, in a quantity of about 0.1% to about 0.5% by weight such that hydrogel has a resistance of less than 10,000 ohms per linear centimeter; and (d) carboxymethylcellulose in an amount of between about 1.1% to 1.7% by weight. - View Dependent Claims (7, 8, 9, 10)
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Specification