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Compositions and methods for administering therapeutically active compounds

  • US 5,070,085 A
  • Filed: 04/06/1990
  • Issued: 12/03/1991
  • Est. Priority Date: 04/10/1987
  • Status: Expired due to Term
First Claim
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1. A therapeutic composition, said composition comprising:

  • (a) an effective amount of a therapeutically active compound, said compound having(i) a molecular weight below about 5,000,(ii) an acidic functional group and a pKa of ≦

    6 at physiological pH=7.4, and(iii) which is normally eliminated unmetabolized via the renal tubular secretion pathway for organic anions;

    and(b) at least one compound selected from the group consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible non-toxic salts, aldono-lactones and aldono-lactides thereof, in an amount effective to increase the body absorption rate of said active compound.

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