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Device for transdermal administration of active medicinal agents

  • US 5,071,657 A
  • Filed: 08/31/1990
  • Issued: 12/10/1991
  • Est. Priority Date: 09/12/1983
  • Status: Expired due to Fees
First Claim
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1. An agent useful for transdermal administration of a pharmacologically active agent, comprising:

  • (a) a matrix of a pharmacologically acceptable crosslinked, silicone elastomer, comprising;

    (i) 1-10% by weight of a polydimethylhydrogensiloxane having an average molecular weight of 300-2000;

    (ii) 1-10% by weight of a 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane; and

    (iii) 10-100 ppm of platinum catalyst in a vinyl group-terminated polydimethylsiloxane having an average molecular weight of 3000-20,000;

    (b) a non-flowable, physiologically acceptable gel microdispersed in said matrix, wherein said gel is based on a combination of a gel-forming thickener, water, and a solvent which is a polyhydric alcohol or a polyvalent ether; and

    (c) an active agent dissolved in the microdispersed gel phase in a concentration of at least 50 wt. % based on the gel phase, wherein said matrix is in the form of a sheet having a thickness of 0.5 to 5 mm.

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