Method of potentiating an immune response
First Claim
1. A method of potentiating the immune response of an animal, comprising the step of parenterally administering to said animal a mixture of effective amounts of first biocompatible microcapsules having a size between approximately 1 micrometer and approximately 10 micrometers and containing a bioactive agent adn second biocompatible microcapsules containing a bioactive agent, said first microcapsules providing a primary immunological response and said second microcapsules releasing said agent contained in said second microcapsules ina pulsed manner to potentiate a subsequent immunological response, wherein said bioactive agent is selected from the group consisting of an antigen and an allergen.
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Abstract
A method of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size ranging from between approximately one micrometer to approximately ten micrometers and admnistering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immuity. Related compositions are also provided.
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Citations
2 Claims
- 1. A method of potentiating the immune response of an animal, comprising the step of parenterally administering to said animal a mixture of effective amounts of first biocompatible microcapsules having a size between approximately 1 micrometer and approximately 10 micrometers and containing a bioactive agent adn second biocompatible microcapsules containing a bioactive agent, said first microcapsules providing a primary immunological response and said second microcapsules releasing said agent contained in said second microcapsules ina pulsed manner to potentiate a subsequent immunological response, wherein said bioactive agent is selected from the group consisting of an antigen and an allergen.
Specification