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Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase

  • US 5,075,229 A
  • Filed: 06/13/1988
  • Issued: 12/24/1991
  • Est. Priority Date: 06/16/1987
  • Status: Expired due to Fees
First Claim
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1. A method of introducing a gene into the liver cells of a mammal in utero which comprises providing a retroviral vector bearing an expressible gene which is foreign to an individual recipient fetal mammal and operably linked to a liver-specific promoter, injecting the vector into the peritoneal cavity of said mammal while it is in a fetal stage of development, and permitting development of said mammal from the fetal stage, during which development the vector is transported to the fetal liver, infects endogenous hemopoietic cells of said fetal liver, and integrates into the genome of said cells conferring on said infected cells the ability to express said gene.

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