Polymer supersurfactants for protein resistance and protein removal

• US 5,075,400 A
• Filed: 03/14/1990
• Issued: 12/24/1991
• Est. Priority Date: 09/22/1988
• Status: Expired due to Fees

• Current Assignee: University of Utah (State of Utah)
• Original Assignee: University of Utah (State of Utah)
• Inventors: Lee, Jin H., Kopecek, Jindrich, Andrade, Joseph D.
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): Smith, Jeffrey T.
• Application Number:
  US07/493,215
• Time in Patent Office: 650 Days
• Field of Search: 526/318.41, 526/307.5, 526/312, 526/320
• US Class Current: 526/307.5
• CPC Class Codes: C08F 220/28 containing no aromatic rings in the alcohol moiety
• CPC Class Codes: C08F 220/286 and containing polyethylene oxide in the alcohol moiety, e.g. methoxy polyethylene glycol (meth)acrylate

Abstract

The invention discloses the processes and materials for treating materials to minimize the deposition of proteins and other molecules, and for removing proteins and other molecules from materials. New copolymers containing polyethylene oxide sidechains called supersurfactants have the ability to bind themselves to interfaces to provide a stable protein-resistant interface. A process is presented to treat and modify interfaces with the new copolymers.

Claims

1. Aqueous solutions of soluble polymers and copolymers containing PEO chains together with alkyl chains to provide optimum adsorption onto hydrophobic surfaces, including polyolefins, acrylates, methacrylates, vinyl polymers, hydrophobic block copolymers, such as polyurethanes, and all other polymers and copolymers whose advancing water contact angle is greater than 20°

;

such soluble polymers and copolymers containing not less than 5% by weight of monomer units A, where A can be represented by the formula;

##STR4## where X is 6 to 200, R₁ is H or CH₃ and R₂ is H or C₁ to C₈ alkyl.

2. Aqueous solutions of soluble polymers and copolymers as set forth in claim 1, wherein the soluble polymers and copolymers have components bearing respective negative or positive charges to provide optimum adsorption and binding onto respective positive or negative surfaces.

3. Aqueous solutions of soluble polymers and copolymers as set forth in claim 1, wherein the amount of PEO-containing monomer is in the range of 5 to 90% by weight.

4. Aqueous solution of soluble polymers and copolymers as set forth in claim 1, in which one of said comonomers is of the formula:

##STR5## where R₃ is C₁ to C₂ alkyl.

5. Aqueous solutions of soluble polymers and copolymers as set forth in claim 1, wherein one of said comonomers is of the formula:

##STR6## where R₄ and R₅ are H or C₁ -C₈ alkyl, acrylic acid, methacrylic acid, diacetone, acrylamide, N-vinyl pyrrolidone, diethylaminoethyl methacrylate, and dimethylaminoethyl methacrylate.