Apparatus and method for resultant-weight measuring system

• US 5,076,107 A
• Filed: 12/27/1988
• Issued: 12/31/1991
• Est. Priority Date: 12/27/1988
• Status: Expired due to Fees

• Current Assignee: GD Searle LLC (Pfizer Inc.)
• Original Assignee: GD Searle LLC (Pfizer Inc.)
• Inventors: Timmermans, Jacques, Moes, Andre J.
• Primary Examiner(s): Noland, Tom
• Application Number:
  US07/289,841
• Time in Patent Office: 1,099 Days
• Field of Search: 73/580, 73/437, 73/432.1, 73/865.8, 73/866, 73/866.2, 73/865, 177/187, 177/210 FP, 177/50
• US Class Current: 73/866
• CPC Class Codes: G01N 13/00 Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects scanning-probe techniques or apparatus G01Q
• CPC Class Codes: G01N 2013/006 Dissolution of tablets or the like
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008
• CPC Class Codes: G01N 5/04 by removing a component, e.g. by evaporation, and weighing the remainder
• CPC Class Codes: G01N 9/08 by measuring buoyant force of solid materials by weighing both in air and in a liquid

Abstract

Apparatus and method are described for measuring and recording as a function of time the resultant-weight of a test object immersed in a fluid medium. The apparatus and method are particularly suitable for determining a change in a chemical and/or physical property of a material exposed to a fluid, and for measurements such as of the floating forces produced by buoyant pharmaceutical dosage forms. An electronic toploader balance, with a weight-transmitter device connected to an electromagnetic measuring module of the balance, is positioned above a container so that the lower end of the weight-transmitter device extends into a solvent within the container. The weight transmitter device performs the double function of holding the test object submerged in the solvent and of transmitting to the balance the reacting force, that is the resultant-weight of the test object.

Claims

1. Apparatus for determining a change in the weight or volume of a test object in an immersed condition as a function of time, said apparatus comprising:

means for securing a test object partially or totally immersed within a liquid medium;

means for detecting the magnitude of resultant weight of said test object;

means connecting said test object securing means and said resultant weight detecting means for transmitting the resultant force acting on said test object from said test object securing means to said resultant weight detecting means, aid test object securing means being characterized by having a waist of relatively small diameter which lies approximately at the surface of the liquid medium when said test object is in an immersed condition;

whereby changes in the resultant weight of the test object in its immersed condition may be determined by changes in the resultant force acting on the test object.

2. The apparatus of claim 1 wherein said waist ensures a reproducible immersion depth of said test object in its immersed condition in the liquid medium.

3. The apparatus of claim 2 wherein said test object securing means is fabricated of a material which is non-porous, non-absorbing of humidity, solvent-resistant and has an insignificant thermic dilation coefficient.