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Process and apparatus for removal of DNA and viruses

  • US 5,076,933 A
  • Filed: 06/29/1990
  • Issued: 12/31/1991
  • Est. Priority Date: 06/29/1990
  • Status: Expired due to Term
First Claim
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1. A process for the removal of DNA, endotoxins and viruses from aqueous buffer solutions, aqueous pharmaceutical solutions and aqueous biological pharmaceutical solutions comprising, passing one of said aqueous buffer solutions, aqueous pharmaceutical solutions and aqueous biological pharmaceutical solutions through a first DNA filter section and a second virus filter section, wherein said DNA, viruses and endotoxins are substantially removed;

  • and collecting said aqueous buffer solutions, aqueous pharmaceutical solutions or aqueous biological pharmaceutical solutions;

    said first DNA filter having;

    (i) a first absolute pore filter,(ii) a first and second filter selected from one of (a) a DEAE cellulose filter membrane and (b) an absolute pore filter coated with at least one of DEAE cellulose, quaternary aminoethyl salts and quaternary aminomethyl salts, and(iii) a second absolute pore filter; and

    said second virus filter section having absolute pore filters of smaller pore diameter than the absolute pore filters in the DNA filter section.

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