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Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent

  • US 5,077,210 A
  • Filed: 01/13/1989
  • Issued: 12/31/1991
  • Est. Priority Date: 01/13/1989
  • Status: Expired due to Term
First Claim
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1. A method for modifying a substrate to activate said substrate for the immobilization of anzime group-containing active agents, said method comprising,selecting a substrate having hydroxyl groups on at least one surface,coating said hydroxyl-containing surface with a thiol-terminal group silane containing a reactive group other than a thiol group that reacts only with the hydroxyl groups on said surface to form a silane layer having an available reactive thiol group,coating said silane layer with a heterobifunctional succinimide group-containing crosslinking agent having a functional group other than the succinimide group that reacts only with the thiol-terminal group on said silane to form a layer of crosslinking agent having an available free succinimide reactive group capable of reacting with amino group of said active agent.

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