Flexible lubricious organic coatings

• US 5,077,352 A
• Filed: 04/23/1990
• Issued: 12/31/1991
• Est. Priority Date: 04/23/1990
• Status: Expired due to Term

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Elton, Richard K.
• Primary Examiner(s): Bleutge, John C.
• Assistant Examiner(s): Hamilton, III, Thomas
• Application Number:
  US07/512,872
• Time in Patent Office: 617 Days
• Field of Search: 525/409, 525/453
• US Class Current: 525/409
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: C08G 18/0857 the solvent being a polyol
• CPC Class Codes: C08G 18/36 Hydroxylated esters of higher fatty acids
• CPC Class Codes: C08G 18/4018 Mixtures of compounds of group C08G18/42 with compounds of group C08G18/48
• CPC Class Codes: C08G 18/4833 Polyethers containing oxyethylene units
• CPC Class Codes: C08G 18/8029 Masked aromatic polyisocyanates
• CPC Class Codes: C08L 71/00 Compositions of polyethers obtained by reactions forming an ether link in the main chain of polyacetals C08L59/00; of epoxy resins C08L63/00; of polythioether-ethers C08L81/02; of polyether-sulfones C08L81/06; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C09D 175/04 Polyurethanes

Abstract

A flexible, lubricious organic polymeric coating is formed by applying a mixture of an isocyanate, a polyol, poly(ethylene oxide), and carrier liquid to a surface to be coated. The carrier liquid is removed and the mixture reacted to form a polyurethane coating with associated poly(ethylene oxide) giving a highly lubricious, abrasion resistant, flexible coating particularly suitable for use as a protective lubricious coating on devices introduced into the body.

Claims

1. A method of preparing an abrasion resistant hydrophilic lubricious, organic coating on an organic substrate to be coated,

said method comprising forming a mixture of an isocyanate, a polyol and a poly(ethylene oxide) in a carrier liquid, removing at least a portion of said carrier liquid, and heating and curing to form a coating substantially of a polyurethane complexed with poly(ethylene oxide) having good adherence to the substrate and good anti-friction properties.

2. A method of forming an abrasion resistant coating in accordance with claim 1 wherein said mixture has a stoichimetric ratio of total NCO groups to total OH groups in the range of from 0.05 to 1.5.

3. A method in accordance with claim 2 wherein said carrier liquid is an organic solvent capable of solubilizing said polyol, isocyanate and poly(ethylene oxide).

4. A method of preparing an abrasion resistant, hydrophilic, lubricious organic coating comprising,

forming a reaction mixture containing an isocyanate, a polyol and a poly(ethylene oxide) having a molecular weight in the range of from 50,000 to 5,000,000,

said mixture being dissolved in a solvent to form a uniform solution,

applying said solution to an organic substrate to form a coating,

removing said solvent,

and curing said coating to allow said polyol and isocyanate to react to form a cross-linked substantially polyurethane matrix associated with the poly(ethylene oxide).

5. A method in accordance with the method of claim 4 wherein said curing is carried out at a temperature of 70°

F. to 350°

F. for a time period of from 2 minutes to 72 hours.

6. A method in accordance with the method of claim 4 wherein said substrate is a catheter and said coating overlies said catheter.

7. A method in accordance with the method of claim 6 wherein isocyanate and polyol have a ratio to poly(ethylene oxide) of from 0.25 to 6.0.