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Segmented electrophoretic separation system useful for lipid profiling

  • US 5,078,853 A
  • Filed: 03/22/1991
  • Issued: 01/07/1992
  • Est. Priority Date: 03/22/1991
  • Status: Expired due to Term
First Claim
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1. A diagnostic apparatus useful for electrophoretic fractionation of charged particles having different molecular weights within a liquid sample comprising:

  • a plurality of gel matrixes defining a liquid pathway upon which a directional electrophoretic gradient can be imposed and each gel matrix defining a boundary generally transverse to the fluid pathway, the gel matrixes being in a serial relationship with a one being upstream relative a downstream other;

    means for introducing the liquid sample into the liquid pathway upstream of the one gel matrix; and

    ,a plurality of collecting means disposed in the liquid pathway and associated with the gel matrix boundaries, the collecting means defining a plurality of interfaces between the gel matrixes, the interfaces each corresponding to a different molecular size fraction of charged particles, the collecting means for permitting passage of charged particles through an interface when the charged particles are smaller than the molecular size fraction to which that interface corresponds and for collecting charged particles at that interface when the charged particles are larger than the molecular size fraction to which the interface corresponds.

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