Time release protein

• US 5,079,005 A
• Filed: 06/05/1989
• Issued: 01/07/1992
• Est. Priority Date: 06/17/1988
• Status: Expired due to Term

• Current Assignee: Kashmiri L. Gupta
• Original Assignee: Nurture Biotech, Inc.
• Inventors: Gupta, Kashmiri L.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Benston, Jr., William E.
• Application Number:
  US07/362,033
• Time in Patent Office: 946 Days
• Field of Search: 424/499, 424/419, 424/490, 424/408, 424/405, 424/76.4, 424/65
• US Class Current: 424/408
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/26 in coated particulate form
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0279 Porous; Hollow
• CPC Class Codes: A61K 8/645 Proteins of vegetable origin; Derivatives or degradation products thereof
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61L 9/04 using substances evaporated in the air without heating
• CPC Class Codes: A61L 9/042 with the help of a macromolecular compound as a carrier or diluent A61L9/048 takes precedence
• CPC Class Codes: A61Q 17/02 containing insect repellants
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

Disclosed is a porous protein particle for delivering over a period of time an active ingredient impregnated therein, and methods of making and using the same. The protein particles have a median size less than about 50 microns. Active ingredient entrapped in the porous structure is gradually released from the protein particle.

Claims

1. A method for delivering an active ingredient over time, comprising the steps of:

a. providing a plurality of porous seed protein particles which differ from the naturally occurring seed protein in that at least a portion of the lipid materials naturally occurring in the seed have been removed from said particles, said particles having an active ingredient contained within the pores thereof in such a manner that it can migrate out of said pores, said particles having a median particle size sufficiently small that without said active ingredient, said particles are in the form of a free flowing powder; and

b. permitting the active ingredient to migrate out of the pores to provide a sustained release of the active ingredient over a period of at least 20 minutes.

2. A method as in claim 1 wherein the permitting step is responsive to a predetermined enabling event.

3. A method as in claim 2 wherein the enabling event is a change in pH.

4. A method as in claim 2 wherein the enabling event is a change in temperature.

5. A method as in claim 2 wherein the enabling event is exposure to ultraviolet light.

6. A method as in claim 2 wherein the enabling event is exposure to a solvent for the active ingredient.

7. The method of claim 1, wherein said active ingredient is lipopilic.

8. The method of claim 1, wherein said active ingredient is a pharmaceutical.

9. The method of claim 1, wherein said active ingredient is a cosmetic material.

10. The method of claim 1, wherein said active ingredient is a pesticide.

11. The method of claim 1, wherein said active ingredient is a pest repellant.