Procedure for reducing the body burden of HIV (AIDS) and other blood borne infections

• US 5,080,645 A
• Filed: 10/31/1989
• Issued: 01/14/1992
• Est. Priority Date: 10/31/1989
• Status: Expired due to Term

• Current Assignee: Joseph P. Hanig
• Original Assignee: Joseph P. Hanig
• Inventors: Hanig, Joseph P.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Polutta, Mark O.
• Application Number:
  US07/429,623
• Time in Patent Office: 805 Days
• Field of Search: 604/4, 604/49, 604/52, 604/7, 604/51, 604/48, 604/5, 128/898, 128/897, 514/661, 514/832
• US Class Current: 604/5.02
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions

Abstract

The foregoing emergency replacement procedure or method for rapid and drastic reduction of the body burden of AIDS virus residing primarily in the formed elements of the blood involves the removal of all blood from the patient and replacement with an emulsion of a perfluorocarbon chemical or other blood substitute, several exchanges of blood substitute in order to attempt a "scrubbing" in totality of the AIDS containing blood from all of the tissues and organs served by vascular beds and then replacement of the emulsion of perfluorocarbon chemical or other blood substitute with whole blood of the same type as the patient; and wherein the above replacement procedure is carried out using antiviral agents or other agents currently shown to reduce, mitigate or destroy the AIDS virus during and after the above said replacement procedure.

Claims

1. A method for reducing the body burden of a blood borne infection in a patient comprising the steps of:

A) substantially or completely replacing the blood of a patient having a blood born infection with a synthetic blood substitute, and as part of a continuous process;

B) subsequently replacing said synthetic blood substitute with whole blood, thereby reducing the number of infected cells in said patient.

2. The method of claim 1, wherein after step A but before step B, said synthetic blood substitute is partially or substantially completely replaced one or more times with additional quantities of a synthetic blood substitute.

3. The method of claim 1, wherein steps A and B are carried out under clinical cryogenic conditions of lowered body temperature which reduce the patient'"'"'s need for oxygen.

4. The method of claim 1, wherein steps A and B are carried out under conditions of supplemented oxygen up to 100%.

5. The method of claim 1, wherein steps A and B are carried out under conditions of hyperbaric pressure.

6. The method of claim 1, wherein steps A and B are carried out as rapidly as clinically possible.

7. The method of claim 1, wherein at least one therapeutic agent for said blood born infection is administered to said patient in said synthetic blood substitute, concurrently with said synthetic blood substitute, or subsequent to step B.

8. The method of claim 1, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

9. The method of claim 1, wherein said synthetic blood substitute comprises a synthetic hemoglobin substitute.

10. A method for reducing the body burden of AIDS virus in a patient having AIDS comprising the steps of:

A) substantially or completely replacing the blood of an AIDS patient with a synthetic blood substitute, and as part of a continuous process;

B) replacing said synthetic blood substitute with whole blood, thereby reducing the number of infected cells in said patient.

11. The method of claim 10, wherein after step A but before step B, said synthetic blood substitute is partially or substantially completely replaced one or more times with additional quantities of a synthetic blood substitute.

12. The method of claim 10, wherein steps A and B are carried out under clinical cryogenic conditions of lowered body temperature which reduce the patient'"'"'s need for oxygen.

13. The method of claim 10, wherein steps A and B are carried out under conditions of supplemented oxygen up to 100%.

14. The method of claim 10, wherein steps A and B are carried out under conditions of hyperbaric pressure.

15. The method of claim 10, wherein steps A and B are carried out as rapidly as clinically possible.

16. The method of claim 10, wherein at least one therapeutic agent for said AIDS infection is administered to said patient in said synthetic blood substitute, concurrently with said synthetic blood substitute, or subsequent to step B.

17. The method according to claim 10, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

18. The method according to claim 11, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

19. The method according to claim 12, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

20. The method according to claim 13, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

21. The method according to claim 14, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

22. The method according to claim 15, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

23. The method according to claim 16, wherein said synthetic blood substitute comprises a perfluorocarbon compound.

24. The method of claim 10, wherein said synthetic blood substitute comprises a synthetic hemoglobin substitute.

25. The method of claim 11, wherein said synthetic blood substitute comprises a synthetic hemoglobin substitute.

26. The method of claim 12, wherein said synthetic blood substitute comprises a synthetic hemoglobin substitute.

27. The method of claim 13, wherein said synthetic blood substitute comprises a synthetic hemoglobin substitute.