Membrane for electrotransport transdermal drug delivery
First Claim
1. An iontophoretic agent delivery electrode assembly adapted for placement on a body surface for iontophoretic delivery of agent therethrough, the electrode assembly including an electrode, a means for connecting said electrode to a source of electrical power, and an agent reservoir containing an agent to be delivered through the body surface, the reservoir being electrically connected to the electrode, the assembly having:
- a membrane for controlling agent delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the agent therethrough and impeding passive flux (JP) of the agent therethrough, the membrane exhibiting a ratio of JEK ;
JP of at least about 2.5.
1 Assignment
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Accused Products
Abstract
A membrane capable of inhibiting agent release from a delivery system when no electrical current is flowing and yet provide minimal impedance to electrically-assisted agent delivery, useful both for incorporating into electrotransport agent delivery systems and for use in measuring agent release rates in in vitro testing.
172 Citations
15 Claims
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1. An iontophoretic agent delivery electrode assembly adapted for placement on a body surface for iontophoretic delivery of agent therethrough, the electrode assembly including an electrode, a means for connecting said electrode to a source of electrical power, and an agent reservoir containing an agent to be delivered through the body surface, the reservoir being electrically connected to the electrode, the assembly having:
- a membrane for controlling agent delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the agent therethrough and impeding passive flux (JP) of the agent therethrough, the membrane exhibiting a ratio of JEK ;
JP of at least about 2.5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- a membrane for controlling agent delivery from the electrode assembly, the membrane being positioned between said reservoir and said body surface, the membrane exhibiting an electrically-assisted flux (JEK) of the agent therethrough and impeding passive flux (JP) of the agent therethrough, the membrane exhibiting a ratio of JEK ;
Specification