Analytical method and apparatus using chemical analytical slides

• US 5,081,038 A
• Filed: 09/19/1990
• Issued: 01/14/1992
• Est. Priority Date: 03/12/1987
• Status: Expired due to Term

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Inventors: Sugaya, Fumio, Endo, Hirotoshi
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): ALEXANDER, LYLE
• Application Number:
  US07/586,324
• Time in Patent Office: 482 Days
• Field of Search: 422/297, 422/57, 422/63, 422/64, 422/72, 436/527, 436/63, 436/808, 436/46
• US Class Current: 436/46
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00138 Slides
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: Y10T 436/112499 with sample on test slide

Abstract

An analytical method using chemical analytical slides which includes the steps of: placing liquid samples in an automatic sampler of an analyzer, loading in to said analyzer the chemical analytical slides combined in groups according to respective analytes to be measured in each sample, including a partition plate interposed between said groups of the chemical analytical slides, and changing over the sample to be spotted on the chemical analytical slide by means of said automatic sampler when said partition plate is detected.

By employing this method, the sample to be spotted can be precisely and synchronously changed, and therefore, serious error is prevented that might occur if the analytical result of a different person is used to distinguish between analytes. Moreover, the analytical operation is simple and highly efficient.

Claims

1. A method of automatically dispensing samples onto chemical analytical slides in an automatic analytical analyzer comprising the steps of:

placing liquid samples in an automatic sampler of an analyzer;

arranging chemical analytical slides by groups according to respective analyzes to be measured for each of said samples;

interposing a partition plate which is optically discriminable from said chemical analytical slides between adjacent ones of said groups of said chemical analytical slides;

loading said chemical analytical slides and said partition plate in said analyzer;

automatically moving said groups of said chemical analytical slides and said partition plate along a path through a dispensing station to a chemical analyzer;

dispensing a first one of said samples onto a first one of said groups of chemical analytical slides at said dispensing station;

detecting the presence of said partition plate between said groups of said chemical analytical slides in said path; and

in response to the detection of said partition plate, immediately dispensing a second one of said samples onto a next adjacent group of chemical analytical slides at said dispensing station.

2. The analytical method of claim 1, further comprising the step of moving said samples relative to said dispensing station;

and

wherein said loading step comprises vertically stacking said groups of chemical analytical slides and said partition plate in said analyzer; and

wherein each dispensing step comprises drawing a sample into a pipette and dispensing the samples from said pipette onto said groups of slides at said dispensing station.

3. The analytical method of claim 1, wherein said loading step comprises stacking said groups of chemical analytical slides and said partition plate in said analyzer.

4. The analytical method of claim 1, further comprising the steps of:

moving said samples relative to said dispensing station; and

arranging said samples so that respective ones of said samples are fed to said dispensing station in the same order as corresponding groups of slides are moved through said dispensing station.

5. The analytical method of claim 1, further comprising the step of:

providing said partition plate with an identification mark identifying said partition plate as a partition plate.

6. The analytical method of claim 5, further comprising the step of:

making said partition plate white without opaque bars.

7. The analytical method of claim 5, further comprising the step of forming said identification mark as two bars.

8. The analytical method of claim 5, further comprising the steps of:

providing said partition plate with a sample identifying code;

providing respective identifying codes on containers containing said samples; and

moving into said dispensing station a container carrying a sample-identifying code corresponding to said sample-identifying code on said partition plate.

9. The analytical method of claim 5, wherein said identification mark is a bar code, and further comprising the step of providing an identical bar code on a container of one of said samples to be dispensed on said second group of chemical analytical slides at said dispensing station;

and

moving said container having said bar code identical to said bar code on said partition plate so as to dispense said one of said samples onto said next adjacent group of slides at said dispensing station.

10. The analytical method of claim 9, further comprising a step of providing an order of a plurality of containers in said analyzer inconsistent with an order of said chemical analytical slides loaded in said analyzer.

11. An automatic dispensing apparatus for an analytical analyzer comprising:

means for storing a plurality of chemical analytical slides and a partition plate, said plurality of chemical analytical slides being arranged in groups and said partition plate dividing adjacent groups of chemical analytical slides, wherein said partition plate is optically discriminable;

means for storing a plurality of samples;

means for automatically moving said chemical analytical slides and said partition plate through a dispensing station to a chemical analyzer;

means for selectively dispensing said samples onto respective groups of said chemical analytical slides at said dispensing station;

means for detecting the presence of said partition plate dividing adjacent groups of chemical analytical slides; and

means, responsive to an output signal from said detecting means representing a detection of said partition plate, for moving one of said samples into said dispensing station so that said one of said samples is immediately dispensed onto its respective group of chemical analytical slides.

12. An apparatus of claim 11, wherein said means for storing samples comprises a rotatable tray having disposed thereon a container for each of said samples.

13. An apparatus of claim 11, wherein said dispensing means comprises a pipette movable between said containers and said dispensing station.

14. An apparatus of claim 11, wherein said means for detecting comprises means for reading on said slides identification marks identifying sample characteristics to be analyzed, and for reading on said partition plate a sample-identifying code;

wherein said means for storing chemical analytical slides comprises a cartridge for vertically storing said slides and said partition plate;

wherein said means for storing samples comprises a rotatable tray having disposed thereon a plurality of containers for respective samples, each container having a sample-identifying code; and

wherein said means for moving said samples comprises means for reading said code on said container and rotates said tray so that a sample in a container, having a sample-identifying code corresponding to said sample identifying code on said partition plate, is dispensed at said dispensing station.

15. The apparatus of claim 14, wherein an order of said containers positioned on said rotatable tray is inconsistent with an order of said chemical analytical slides stacked in said cartridge.