Wound dressing protocol utilizing collagen gelatin formed with iodine

• US 5,081,106 A
• Filed: 07/16/1990
• Issued: 01/14/1992
• Est. Priority Date: 07/16/1990
• Status: Expired due to Fees

• Current Assignee: Oregon Health & Science University
• Original Assignee: Oregon Health & Science University
• Inventors: Fellman, Jack H., Bentley, J. Peter
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): Criares, T. J.
• Application Number:
  US07/553,979
• Time in Patent Office: 547 Days
• Field of Search: 424/443, 424/445, 424/446, 424/447, 424/667, 424/668, 514/801
• US Class Current: 514/9.4
• CPC Class Codes: A61K 33/18 Iodine; Compounds thereof
• CPC Class Codes: A61L 2300/106 Halogens or compounds thereof, e.g. iodine, chlorite
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 26/0033 Collagen
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides

Abstract

A stabilized collagen gel is disclosed as are methods of making this collagen gel which is useful as a wound dressing to prevent dehydration of the subject being treated and infection of the wound. The collagen gel of the invention is stabilized by combining collagen (preferably a pharmaceutical grade collagen, which is atelopeptide collagen), with iodine or a composition capable of generating iodine. The collagen is flowable on first mixing and undergoes a phase transition to form a stable gel with sufficient structural integrity to form a wound dressing.

Claims

1. A collagen gel composition, comprising:

a water soluble collagen material;

water present in sufficient amount relative to the collagen such that the water and collagen form a solution; and

an iodine or iodine-generating composition present in sufficient amount relative to the solution that the solution undergoes a phase transition from the solution to a gel, the phase transition occurring in ten minutes or less at a temperature in the range of 20°

C. to 28°

C.

2. The composition of claim 1, wherein said iodine generating composition is an oxidized iodine in combination with a reducing agent.

3. The composition of claim 2, wherein said oxidized iodine is selected from the group consisting of alkali metal iodate, periodate and iodine pentoxide.

4. The composition of claim 1, wherein the iodine generating composition includes an acidic pH buffer or other proton source present in sufficient amount to insure iodine release.

5. The composition of claim 1, wherein the soluble collagen is atelopeptide collagen and is present in combination with buffer salts.

6. The composition as claimed in claim 5, wherein the buffer is a citrate/phosphate buffer.

7. The composition of claim 1, wherein said iodine generating composition is a reduced iodine in combination with an oxidizing agent and an additional compound which acts as a source of protons.

8. The composition as claimed in claim 7, wherein the reduced form of iodine is potassium iodide, and the oxidizing agent is selected from the group consisting of persulfates, perborates, hydrogen peroxide, tertary butyl peroxide, alkali metal periodate, hypochlorite salts and free hypochlorous acid and halogen amines.

9. The composition as claimed in claim 8, wherein the source of protons is citric acid.

10. A method of forming a collagen gel, comprising the steps of:

combining collagen and water in relative amounts so as to form an aqueous collagen solution; and

combining a composition capable of generating iodine in solution with the collagen solution in relative amounts so that the solution undergoes a phase transition from the solution to a gel, the phase transition occurring in ten minutes or less at a temperature in the range of 20°

C. to 28°

C.

11. The method of claim 10, wherein said composition capable of generating iodine is comprised of an oxidized iodine in combination with a reducing agent.

12. The method of claim 10, wherein said oxidized iodine is selected from the group consisting of alkali metal iodate, periodate, iodine pentoxide.

13. The method of claim 10, wherein the composition capable of generating iodine is comprised of a reduced iodine in combination with an oxidizing agent.

14. The method as claimed in claim 13, wherein the reduced iodine is potassium iodide and the oxidizing agent is selecting form the group consisting of persulfates, perborates, hydrogen peroxide, tertary butyl peroxide, alkali metal periodate, hypochlorite salts and free hypochlorous acid and halogen amines.

15. The method as claimed in claim 14, wherein the composition capable of generating iodine is further comprised of a proton donor and the collagen is atelopeptide collagen.

16. The composition as claimed in claim 15, wherein the proton donor is citric acid and the atelopeptide collagen is a pharmaceutical grade Type I collagen.

17. A method of treating a wound, comprising the steps of:

combining collagen and water in relative amounts so as to provide an aqueous collagen solution;

forming a wound-healing composition by combining a composition capable of generating iodine in solution with the collagen solution in relative amounts so that the collagen solution will undergo a phase transition from the solution to a gel which phase transition would occur in ten minutes or less at a temperature in the range of 20°

to 28°

C.;

applying the wound-healing composition to the wound while the composition is in a solution phase;

allowing the solution to conform to the shape of the wound and undergo the phase transition from solution to gel on the wound.