Methods and apparatus for the examination and treatment of internal organs

• US 5,081,993 A
• Filed: 05/09/1990
• Issued: 01/21/1992
• Est. Priority Date: 11/11/1987
• Status: Expired due to Term

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Circulation Research Limited
• Inventors: Kitney, Richard I., Rothman, Martin T., Straughan, Keith
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): Manuel, George
• Application Number:
  US07/488,007
• Time in Patent Office: 622 Days
• Field of Search: 128/661.08, 128/661.09, 128/660.03, 128/916, 128/662.06, 128/4, 128/660.09, 128/24 A
• US Class Current: 600/455
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4438 Means for identifying the diagnostic device, e.g. barcodes
• CPC Class Codes: A61B 8/4488 the transducer being a phased array
• CPC Class Codes: A61B 8/4494 characterised by the arrangement of the transducer elements devices for short-range imaging using particular transducer elements arrangements under G01S15/8909; arrangements of transducers in generation of mechanical vibrations of infrasonic, sonic or ultrasonic frequency B06B1/0607
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: B06B 1/0625 Annular array
• CPC Class Codes: G01S 15/892 the array being curvilinear
• CPC Class Codes: G01S 15/8922 the array being concentric or annular
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: G01S 15/8993 Three dimensional imaging systems
• CPC Class Codes: Y10S 128/916 Ultrasound 3-D imaging

Abstract

The internal examination of a human organ (3) is made by means of an ultrasonic probe (2) inserted into the organ (3), analogue echo signals from the probe being converted to digital signals (8) which are then stored in a digital computer (10) where they are manipulated to produce a variety of three-dimensional representations of the interior of the organ for display on a terminal (12) or as hard copy (13).

Claims

1. A method for providing an image of the interior of a human organ or for visualising the flow of blood through it comprising the steps of:

firing ultrasonic signals either from inside or outside the organ,

detecting echo signals of said fired ultrasonic signals,

digitising the echo signals,

storing the digitised echo signals in a digital computer,

manipulating the stored digitised echo signals in such a way as to provide an output from the computer which will give a three-dimensional visual representation of the interior of the organ, and

enabling manipulation of the representation to enable the representation to be viewed from different aspects.

2. A method as claimed in claim 1 in which a three-dimensional representation or model of the human organ is created by means of the following steps:

(a) obtaining a first approximation to an instantaneous cross-sectional shape or "slice" of the organ by means of the said echo signals;

(b) Digitising signals corresponding to each "slice" into two-dimensional elements or "pixels";

(c) Interpolating between points on the cross-section defined by the said echo signals to provide a second approximation to the said instantaneous cross-sectional shape or "slice";

(d) Integrating a plurality of the bus generated "slices" and interpolating between adjacent "slices" to form a three-dimensional representation of three-dimensional elements or "voxels"; and

(e) Manipulating the said three dimensional elements or "voxels" to produce a variety of three-dimensional representations of the organ.

3. A method as claimed in claim 1 further comprising the step of superimposing the three-dimensional ultrasonic image on an X-ray image.

4. A method as claimed in claim 1 in which a representation of a flow of blood in the human organ is created by means of the following steps:

(a) doppler demodulating the stored digitised echo signals to extract a doppler signal therefrom;

(b) performing a spectral estimation on the doppler signal to calculate the spectral features of the doppler signal;

(c) performing a velocity estimation on the spectrally estimated signal to calculate fluid flow velocity information;

(d) performing a three dimensional fluid flow generation to produce a three dimensional flow profile calculation and representation; and

(e) manipulating the representation produced by step (d) to enable the representation to be viewed from different aspects on a display terminal.

5. Equipment for providing an image of the interior of a human organ within a human body, comprising:

(a) a catheter for insertion into the human body;

(b) an ultrasonic transducer assembly mounted on the catheter;

(c) means for energising the transducer assembly to generate ultrasonic signals;

(d) means for receiving the resultant ultrasonic echo signals and converting them into digital signals;

(e1) a digital computer;

(e2) means for supplying the digital signals from said means for receiving to said digital computer;

(f) means for manipulating the digital signals to enable a three-dimensional representation of the organ to be created and for enabling that representation to itself be manipulated to enable the representation to be viewed from different aspects and also to enable the structural make-up of tissue to be visually represented; and

(g) means connected to the computer for visually displaying the three-dimensional representation.

6. Equipment as claimed in claim 5 which includes means generating a spark at or near the distal end of the catheter and detection means, which in use is external of the patient, for detecting the discharge of the spark and thereby producing signals indicative of the position of the spark and hence the distal end of the catheter in relation to the patient.

7. Equipment as claimed in claim 5 which includes means for measuring and indicating the distance which the distal end of the catheter has been inserted into the patient.

8. Equipment as claimed in claim 5 in which the proximal end of the catheter is provided with means for uniquely identifying that catheter, said identification means being adapted to interact with the ultrasonic transducer assembly and processing the resultant echo signals in order to set up the system automatically for use with that particular catheter.

9. A catheter for insertion into a human body and for use with equipment for providing an image of the interior of a human organ within a human body, the equipment including means for receiving resultant ultrasonic echo signals from ultrasonic signals generated by the catheter and for converting the echo signals into digital signals;

a digital computer;

means for supplying the digital signals from said means for receiving to said digital computer;

means for manipulating the digital signals to enable a three-dimensional representation of the organ to be created and for enabling that representation to itself be manipulated to enable the representation to be viewed from different aspects and also to enable the structural make-up of tissue to be visually represented; and

means connected to the computer for visually displaying the three-dimensional representation, said catheter comprising;

(a) a catheter tube;

(b) a probe carried at one end of the catheter tube;

(c) an ultrasonic transducer arrangement in the form of an annular assembly of transducer elements which encircle the probe at or near one of its ends; and

(d) means for electrically connecting the transducer elements to the other end of the catheter tube, which means either incorporates a multiplexing/demultiplexing circuit or comprises a wiring arrangement which has the effect of acting in a multiplexing or demultiplexing way, either the circuit or the arrangement reducing the number of wires which run the length of the catheter tube.

10. A catheter as claimed in claim 9 in which the annular transducer arrangement comprises a plurality of discrete piezo-electric crystal elements arranged in one or more rings coaxially around one end of the catheter tube.

11. A catheter as claimed in claim 10 in which the probe comprises a one-piece plastics member which is shaped to accommodate the transducer arrangement and which has a spigot portion adapted to fit into one end of the catheter tube.

12. A catheter as claimed in claim 10 in which the probe also has mounted on it a further ultrasonic transducer arrangement which is designed to emit ultrasonic signals of a frequency which in use will tend to disintegrate matter which has accumulated on the inside walls of the human organ.

13. A catheter as claimed in claim 9 in which the annular transducer arrangement comprises one or more rings of piezo-electric crystal material arranged coaxially around one end of the catheter tube, each ring being divided into a plurality of areas of each of which is adapted to operate as a separate ultrasonic signal emitting and receiving element.

14. A catheter as claimed in claims 9 which is adapted to accommodate a fibre optic channel for the application of laser angioplasty.

15. A catheter as claimed in claim 9 which incorporates a balloon mounted around and near the probe, the balloon being inflatable by means of air or gas passed down a lumen in the catheter.

16. A catheter as claimed in claim 9 in which the transducer arrangement is rotatably mounted on the probe and means are provided for driving the arrangement to thereby enable the transducer element or elements to rotate about the axis of the probe and thus scan the interior of the organs.

17. A catheter as claimed in claim 9 in which the transducer arrangement consists of a number of pairs of transducer elements, each transducer element of a pair being inclined inwardly towards the other transducer element of the pair so that when in operation the signals generated by the two transducer elements of a pair will focus at a point radially outwardly from the wall of the catheter, each transducer element of a pair being adapted to emit ultrasonic signals at a different frequency from the other transducer element of that same pair.