External adhesive preparation containing steroids

• US 5,082,663 A
• Filed: 01/11/1991
• Issued: 01/21/1992
• Est. Priority Date: 08/20/1986
• Status: Expired due to Term

• Current Assignee: SS Pharmaceutical Company Limited, Teikoku Seiyaku Kabushiki Kaisha
• Original Assignee: SS Pharmaceutical Company Limited, Teikoku Seiyaku Kabushiki Kaisha
• Inventors: Ishihara, Manabu, Oji, Akihito, Makaya, Osami, Iwasa, Akira, Konishi, Ryoji, Kawaji, Toshikuni
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US07/639,758
• Time in Patent Office: 375 Days
• Field of Search: 424/484, 424/485, 424/486, 424/445, 424/456, 424/78, 424/443, 514/861, 514/863, 514/781, 514/179, 514/182
• US Class Current: 424/445
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/222 Steroids, e.g. corticosteroids
• CPC Class Codes: A61L 26/0066 Medicaments; Biocides

Abstract

An external adhesive preparation comprising a steroid for treatment of skin diseases in admixture with an adhesive gel base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent. The external adhesive preparation is useful for treatment of skin diseases by applying the preparation spread on a soft support directly to diseased parts on the skin, thereby administering the contained steroid to the skin.

Claims

1. An external adhesive preparation for the treatment of skin diseases which consists of an effective amount of a steroid in admixture with an adhesive gel base consisting essentially of a water-soluble high molecular weight compound, water, and a water-retaining agent,

wherein said water-soluble high molecular weight compound is carboxymethylcellulose, methyl cellulose, polyvinyl alcohol, polyacrylic acid, therapeutically effective metal salts thereof, or a combination or two or more thereof, which is contained in an amount of 0.1 to 30 w/w % in the adhesive gel base,

said water-retaining agent being a polyhydric alcohol selected from the group consisting of glycerol, sorbitol, propylene glycol and 1,3-butanediol, which is contained in an amount of 5 to 60 w/w % in an adhesive gel base, or said water-retaining agent having a highly absorptive high molecular weight compound selected from the group consisting of starch - acrylonitrile graft copolymer, starch-acrylic acid graft copolymer, cross-linked product of polyvinyl alcohol, cross-linked product of carboxymethylcellulose, and cross-linked product of polyacrylate, which is contained in an amount of 0.01 to 10.0 w/w % in the adhesive gel base, and

said water being contained in an amount of 20 to 50 w/w % in the adhesive gel base.

2. The adhesive preparation as claimed in claim 1, wherein the amount of the water-soluble high molecular weight compound is in the range of from 0.5 to 15 w/w % of the total preparation.

3. The adhesive preparation as claimed in claim 1, wherein the polyhydric alcohol as the water-retaining agent is contained in an amount of from 10 to 50 w/w % of the total preparation.

4. The adhesive preparation as claimed in claim 1, wherein the highly absorptive high molecular weight compound as the water-retaining agent is contained in an amount of from 0.05 to 7.0 w/w % of the total preparation.

5. The adhesive preparation as claimed in claim 1, wherein the steroid is contained in an amount of from 0.01 to 1 w/w % of the total preparation.

6. The adhesive preparation as claimed in claim 1, wherein the adhesive gel base further contains an additive which is an oil, a surfactant, a stabilizing agent, an antioxidant, a pH controlling agent or an organic filler.

7. The adhesive preparation according to claim 1, wherein the adhesive gel base consists of 0.5 to 15 w/w % of the total preparation of a water-soluble high molecular weight compound being a combination of gelatin, carboxymethylcellulose and carboxymethylcellulose sodium salt, 20 to 50 w/w % of water, and 10 to 50 w/w % of a water-retaining agent being a combination of glycerol and sorbitol.