Pharmaceutical composition for protecting the heart comprising a heterocyclic ethylenediamine derivative and methods for the use thereof
First Claim
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1. A composition for protecting the heart from myocardial ischemia and reperfusion injury comprising a myocardial ischemia and reperfusion injury preventing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a pharmacologically acceptable carrier.
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Abstract
The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'"'"'N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.
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Citations
6 Claims
- 1. A composition for protecting the heart from myocardial ischemia and reperfusion injury comprising a myocardial ischemia and reperfusion injury preventing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a pharmacologically acceptable carrier.
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3. A pharmaceutical composition for reducing post-ischemic damage and improving cardiac function comprising a post-ischemic damage reducing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a pharmacologically acceptable carrier.
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4. A method for the protection and preservation of excorporeal organs comprising immersing an excorporeal organ in an excorporeal organ protecting and preserving effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine.
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5. A method for the protection of biological cells from ischemia and oxygen radical related damage comprising immersing biological cells in a solution which includes an ischemia and oxygen radical related damage preventing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine.
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6. A hypothermic cardiac preservative composition comprising a solution which includes a hypothermic cardiac perserving effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a solvent therefor.
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