Pharmaceutical composition for protecting the heart comprising a heterocyclic ethylenediamine derivative and methods for the use thereof

• US 5,082,851 A
• Filed: 02/07/1990
• Issued: 01/21/1992
• Est. Priority Date: 02/20/1989
• Status: Expired due to Term

• Current Assignee: Minerva Ltd. (Jupiter Properties 2011 UK Ltd.)
• Original Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (Hebrew University of Jerusalem), Hadassah Medical Organization (Yakobovitz Tamir Holdings Limited)
• Inventors: Uretzky, Gideon, Appelbaum, Jerachmiel Y., Chevion, Mordechai
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): Fay, Zohreh A.
• Application Number:
  US07/477,046
• Time in Patent Office: 713 Days
• Field of Search: 514/332
• US Class Current: 514/332
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'"'"'N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.

Claims

1. A composition for protecting the heart from myocardial ischemia and reperfusion injury comprising a myocardial ischemia and reperfusion injury preventing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a pharmacologically acceptable carrier.

2. A composition for protecting the heart from myocardial ischemia and reperfusion according to claim 1 comprising a 5 to 7.5 M concentration of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine in solution.

3. A pharmaceutical composition for reducing post-ischemic damage and improving cardiac function comprising a post-ischemic damage reducing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a pharmacologically acceptable carrier.

4. A method for the protection and preservation of excorporeal organs comprising immersing an excorporeal organ in an excorporeal organ protecting and preserving effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine.

5. A method for the protection of biological cells from ischemia and oxygen radical related damage comprising immersing biological cells in a solution which includes an ischemia and oxygen radical related damage preventing effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine.

6. A hypothermic cardiac preservative composition comprising a solution which includes a hypothermic cardiac perserving effective amount of N,N,N'"'"', N'"'"'-tetrakis-(2-pyridylmethyl)-ethylenediamine and a solvent therefor.