Method of determining calibration curve and apparatus using calibaration curve
First Claim
1. An automatic analyzer, comprising:
- a sample feeding unit having means for containing reaction solutions of a plurality of standard substances having different concentrations;
sampling and analyzing means for sampling and analyzing the reaction solutions of the standard substances plural times, including means for outputting data corresponding to the different concentrations;
central processing means for receiving said data output from said sampling and analyzing means, including;
first means for partially weighting said data by processing a part of said data that corresponds to a predetermined range of said different concentrations to obtain additional data in a predetermined amount that exceeds an amount of said data output by said sampling and analyzing means for said predetermined range;
second means for storing said data together with said additional partially weighted data in memory;
third means for processing the data stored by said second means;
fourth means for calculating a calibration curve from the data processed by said third means;
fifth means for outputting said calibration curve data calculated by said fourth means;
means for receiving said calibration curve data and for displaying the calibration curve; and
said sampling and analyzing means further for sampling and analyzing reaction solutions of said plurality of standard substances in unknown concentration to identify the unknown concentration based on said calibration curve.
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Abstract
A method of determining a calibration curve used in deciding the components of living organism by means of the least-squares method by using a plurality of measured data at different concentrations obtained by measuring reaction solutions of a plurality of standard substances having different concentrations. At least a single set of measured data Y(i) is weighted in a predetermined manner, the measured data Y(i) being obtained from the standard substance reaction solution at a specific concentration X(i) near a limit value used in deciding the living organism components. With the weighting, a calibration curve having a high precision at a portion near the limit value is realized resulting in a correct and highly reliable decision.
45 Citations
4 Claims
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1. An automatic analyzer, comprising:
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a sample feeding unit having means for containing reaction solutions of a plurality of standard substances having different concentrations; sampling and analyzing means for sampling and analyzing the reaction solutions of the standard substances plural times, including means for outputting data corresponding to the different concentrations; central processing means for receiving said data output from said sampling and analyzing means, including; first means for partially weighting said data by processing a part of said data that corresponds to a predetermined range of said different concentrations to obtain additional data in a predetermined amount that exceeds an amount of said data output by said sampling and analyzing means for said predetermined range; second means for storing said data together with said additional partially weighted data in memory; third means for processing the data stored by said second means; fourth means for calculating a calibration curve from the data processed by said third means; fifth means for outputting said calibration curve data calculated by said fourth means; means for receiving said calibration curve data and for displaying the calibration curve; and said sampling and analyzing means further for sampling and analyzing reaction solutions of said plurality of standard substances in unknown concentration to identify the unknown concentration based on said calibration curve.
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2. A method of analyzing including determining a calibration curve for an analyzer, comprising the steps of:
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sampling reaction solutions for a plurality of standard substances having different concentrations; analyzing the reaction solutions sampled in said sampling step to obtain sets of data, each said set corresponding to a respective one of the different concentrations; partially weighting the analysis data by multiplying at least a single said set of the analysis data corresponding to a specific one of the different concentrations of reaction solutions by a predetermined multiplier to obtain a plurality of data corresponding to said specific one of the concentrations of reaction solutions; storing said sets of data and said plurality of data corresponding to said specific one of the concentrations of reaction solutions together; processing said stored data by means of a least-squares method and thereafter generating a calibration curve from said processed data; and sampling and analyzing the reaction solutions of said standard substances having an unknown concentration and determining the unknown concentration based upon said calibration curve. - View Dependent Claims (3)
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4. A method of analyzing including determining a calibration curve for an analyzer, comprising the steps of:
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sampling reaction solutions for a plurality of standard substances having different concentrations; analyzing the reaction solutions sampled in said sampling step a predetermined number of times to obtain data corresponding to the different concentrations; partially weighting the analysis data by analyzing a specific one of the concentrations of reaction solutions a number of times greater than said predetermined number to obtain a plurality of analysis data for said specific one of the concentrations of reaction solutions; storing said analysis data together with said plurality of analysis data for said specific one of the concentrations of reaction solutions; processing said stored data by means of a least-squares method, and thereafter generating a calibration curve from said processed data; and sampling and analyzing reaction solutions of said standard substances having an unknown concentration and determining the unknown concentration based upon said calibration curve.
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Specification