Benzoylaminoquinazolinones
First Claim
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1. A compound of the formula:
- ##STR9## wherein R1 is hydrogen, alkyl(C1 -C3), alkoxy(C1 -C3), trifluoromethyl or halogen;
R2 (when it exists) is hydrogen, alkyl(C1 -C6), or phenyl;
##STR10## R3 (when it exists) is hydrogen or alkyl(C1 -C3);
R4 is hydrogen, halogen, alkyl(C1 -C3);
mono-or dialkoxy(C1 -C3) or --CH═
CH--CH═
CH--;
with the proviso that when R1 is hydrogen or methoxy, then R3 and R4 may not both be hydrogen;
with the further proviso that when R4 is methyl, then R1 and R3 may not both be hydrogen; and
with the still further proviso that when R1 is a methyl group in the 4-position of the phenyl, then R3 and R4 may not both be hydrogen.
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Abstract
This invention is compounds of the formula: ##STR1## and a method of treating cognitive and related neuronal behavioral problems in mammals using the compounds.
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Citations
16 Claims
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1. A compound of the formula:
- ##STR9## wherein R1 is hydrogen, alkyl(C1 -C3), alkoxy(C1 -C3), trifluoromethyl or halogen;
R2 (when it exists) is hydrogen, alkyl(C1 -C6), or phenyl;
##STR10## R3 (when it exists) is hydrogen or alkyl(C1 -C3);
R4 is hydrogen, halogen, alkyl(C1 -C3);
mono-or dialkoxy(C1 -C3) or --CH═
CH--CH═
CH--;
with the proviso that when R1 is hydrogen or methoxy, then R3 and R4 may not both be hydrogen;
with the further proviso that when R4 is methyl, then R1 and R3 may not both be hydrogen; and
with the still further proviso that when R1 is a methyl group in the 4-position of the phenyl, then R3 and R4 may not both be hydrogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16)
- ##STR9## wherein R1 is hydrogen, alkyl(C1 -C3), alkoxy(C1 -C3), trifluoromethyl or halogen;
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15. A method of treating cognitive and related neuronal behavioral problems in a mammal, which comprises administering internally to said mammal a cognition stimulating amount of a compound of the formula:
- ##STR11## wherein R1 is hydrogen, alkyl(C1 -C3), alkoxy(C1 -C3), trifluoromethyl or halogen;
R2 is hydrogen, alkyl(C1 -C6), or phenyl;
##STR12## R3 (when it exists) is hydrogen or alkyl(C1 -C3);
R4 is hydrogen, halogen, alkyl(C1 -C3), mono-or dialkoxy(C1 -C3) or --CH═
CHCH═
CH--.
- ##STR11## wherein R1 is hydrogen, alkyl(C1 -C3), alkoxy(C1 -C3), trifluoromethyl or halogen;
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Current AssigneeAmerican Cyanamid Co (Pfizer Inc.)
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Original AssigneeAmerican Cyanamid Co (Pfizer Inc.)
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InventorsLevin, Jeremy I., Epstein, Joseph W., Fanshawe, William J.
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Primary Examiner(s)Ivy, C. Warren
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Assistant Examiner(s)TURNIPSEED, JAMES
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Application NumberUS07/556,228Time in Patent Office554 DaysField of Search544/289, 544/290, 544/249, 514/260, 514/257US Class Current514/257CPC Class CodesC07D 239/70 condensed with carbocyclic ...C07D 239/94 Nitrogen atoms
