Method of treating inflammatory diseases with pharmaceutical composition containing dihydrolipoic acid as active substance

• US 5,084,481 A
• Filed: 02/08/1990
• Issued: 01/28/1992
• Est. Priority Date: 02/09/1989
• Status: Expired due to Term

• Current Assignee: Evonik Degussa GmbH
• Original Assignee: Asta Pharma Aktiengesellschaft
• Inventors: Engel, Jurgen, Hettche, Helmut, Ulrich, Heinz, Weischer, Carl-Heinrich
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): Jordan, Kimberly R.
• Application Number:
  US07/476,042
• Time in Patent Office: 719 Days
• Field of Search: 514/557, 514/558, 514/706, 514/724, 514/886
• US Class Current: 514/557
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Pharmaceutical compositions and their preparation which contain dihydrolipoic acid or its pharmaceutically acceptable salts as active substance. The pharmaceutical compositions have a cytoprotective effect and are suitable for combatting pain and inflammatory disorders.

Claims

1. A method of treating an inflammatory disease comprising administering, to a patient having an inflammatory disease, an effective anti-inflammatory amount of dihydrolipoic acid or a pharmaceutically acceptable salt thereof.

2. A method as set forth in claim 1 in which the disease which is treated is selected from inflammatory, degenerative articular and extra-articular rheumatic disorders, non-rheumatic inflammatory and swollen states, Arthrosis deformans, chrondropathies, periarthritis, inflammatory disorders of the skin, inflammatory disorders of the gastrointestinal tract, polyneuropathy of diabetic, alcoholic, hepatic and uraemic origin, liver parenchyme degeneration, hepatitis, fatty liver and fatty cirrhosis, chronic liver disorders and inflammatory respiratory tract disorders.