Conveniently carried frequent use autoinjector

• US 5,085,642 A
• Filed: 07/17/1989
• Issued: 02/04/1992
• Est. Priority Date: 07/17/1989
• Status: Expired due to Term

• Current Assignee: Meridian Medical Technologies Incorporated
• Original Assignee: Survival Technology, Inc. (Meridian Medical Technologies Incorporated)
• Inventors: Lopez, Claudio, Sarnoff, Stanley J.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Rafa, Michael
• Application Number:
  US07/380,459
• Time in Patent Office: 932 Days
• Field of Search: 604/95, 604/115, 604/131, 604/134-136, 604/138, 604/139, 604/156-157, 604/171, 604/181, 604/195-196, 604/220, 604/137, 401/243
• US Class Current: 604/134
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287

Abstract

An autoinjector particularly suited to be carried on the person of a user comprising a housing defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen including a housing body assembly of elongated generally cylindrical configuration and a separate housing cap structure of elongated generally cylindrical configuration having an elongated clip thereon. The housing cap structure is detachably secured to the housing body assembly in open ended telescopic relation with an opposite end portion thereof preferably by a childproof connection. A medicament cartridge assembly is mounted in a storage position within a forward end of an interior chamber within the housing body assembly and a releasable stressed spring assembly is carried by the housing body assembly adjacent the rearward end thereof. The housing cap structure serves the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user'"'"'s pocket and (2) alleviating the likelihood of an unwanted release of the releasable stressed spring assembly with a resultant unwanted movement of the hypodermic needle of the cartridge assembly and an unwanted movement of the liquid medicament of the cartridge assembly outwardly of the needle.

Claims

1. An autoinjector comprising

housing means defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen, said housing means including a housing body assembly of elongated generally cylindrical configuration having a needle extension end and an opposite end and a separate housing cap structure of elongated generally cylindrical configuration having an open end and an opposite closed end,

means between said housing body assembly and said housing cap structure for detachably securing said separate housing cap structure in open ended telescopic relation with the opposite end portion of said housing body assembly,

said housing body assembly defining an interior chamber,

a medicament cartridge assembly mounted in a storage position within said interior chamber adjacent the needle extension end of said housing body assembly including a container, a liquid medicament within said container and a hypodermic needle disposed in a storage position and movable therefrom into an extended operative position,

a releasable stressed spring assembly carried by said housing body assembly adjacent the opposite end thereof including spring means, releasable means for retaining said spring means in a stressed storage position within said chamber and releasing means operable in response to a predetermined manual actuating procedure to release said releasable means so that said spring means moves (1) said hypodermic needle into said extended operative position during which the hypodermic needle moves outwardly of the needle extension end of said housing body assembly through the skin and into the adjacent tissue of a user and (2) said liquid medicament outwardly through said hypodermic needle into the tissue of the user,

said releasing means including manually movable means extending from the opposite end of said housing body assembly into an exterior position suitable for manual engagement so as to be manually moved during the manual actuating procedure to which said releasing means is responsive to release said releasable means,

said manually movable means including a safety member mounted in said exterior position extending from the opposite end of said housing body assembly for manual removal from said exterior position, said safety member having means for (1) preventing said releasing means from releasing said releasable means when said safety member is in said exterior position and (2) enabling said releasing means to release said releasable means in response to said predetermined manual actuating procedure which includes an initial manual engagement of said safety member and removal thereof from said exterior position,

said housing cap structure covering said safety member when said housing cap structure is secured to said housing body assembly so as to prevent the manual engagement of said safety member without said housing cap structure being detached from said housing body assembly.

2. An autoinjector as defined in claim 1 wherein said housing body assembly includes a forward housing member defining the needle extension end thereof, a rearward housing member fixed to said forward housing member, and a movable releasing member in telescoping relation with respect to said rearward housing member for limited movement from a storage position into an actuating position, said predetermined manual actuating procedure to which said releasing means is responsive to release said releasable means including a subsequent relative movement of said releasing member in telescoping relation with respect to said rearward housing member into said actuating position by manually moving the same toward said forward housing member while the needle extension end of said housing body assembly is retained in an operative position with the skin of the user at the location where the injection is to take place.

3. An autoinjector particularly suited to be carried on the person of a user comprising

housing means defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen, said housing means including a housing body assembly of elongated generally cylindrical configuration having a needle extension end and an opposite end and a separate housing cap structure of elongated generally cylindrical configuration having an one end and an opposite closed end,

an elongated clip having one end fixed to the exterior of said cap structure adjacent the closed end thereof so as to extend longitudinally therealong and a free end biased to engage with the exterior of said cap structure adjacent the open end thereof whereby said clip serves to secure said cap structure within a pocket on the person of a user,

means between said housing body assembly and said housing cap structure for detachably securing said separate housing cap structure in open ended telescopic relation with an opposite end portion of said housing body assembly so that the latter is secured together with said cap structure within such pocket by said clip,

said housing body assembly defining an interior chamber,

a medicament cartridge assembly mounted in a storage position within said interior chamber adjacent the needle extension end of said housing body assembly including a container, a liquid medicament within said container and a hypodermic needle disposed in a storage position and movable therefrom into an extended operative position,

a releasable stressed spring assembly carried by said housing body assembly adjacent the opposite end thereof including spring means, releasable means for retaining said spring means in a stressed storage position within said chamber and releasing means operable in response to a predetermined manual actuating procedure to release said releasable means so that said spring means moves (1) said hypodermic needle into said extended operative position during which the hypodermic needle moves outwardly of the needle extension end of said housing body assembly through the skin and into the adjacent tissue of a user and (2) said liquid medicament outwardly through said hypodermic needle into the tissue of the user,

said releasing means including manually movable means extending beyond the opposite end portion of said housing body assembly into an exterior position suitable for manual engagement so as to be manually moved during the manual actuating procedure to which said releasing means is responsive to release said releasable means,

said housing cap structure covering said manually movable means when said housing cap structure is secured to said housing body assembly so as to prevent the manual engagement of said manually movable means without said housing cap structure being detached form said housing body assembly thereby enabling said housing cap structure to serve the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user'"'"'s pocket and (2) alleviating the likelihood of an unwanted release of the releasable means with a resultant unwanted movement of said hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle,

said housing body assembly including a forward housing member defining the needle extension end thereof, a rearward housing member fixed to said forward housing member, and a movable tubular releasing member mounted in telescoping relation with respect to said rearward housing member for limited movement from a storage position into an actuating position,

said predetermined manual actuating procedure to which said releasing means is responsive to release said releasable means including a relative movement of said releasing member in telescoping relation with respect to said rearward housing member into said actuating position by manually moving the same toward said forward housing member with a thumb while the needle extension end of said housing body assembly is retained in an operative position with the skin of the user at the location where the injection is to take place,

said manually movable means including a safety member mounted in said exterior position extending from the opposite end of said housing body assembly for manual removal form said exterior position, said safety member having means for (1) preventing said movement of said tubular member toward said forward housing member when said safety member is in said exterior position and (2) enabling said movement of said tubular member toward said forward housing member when said safety member is removed from said exterior position,

said predetermined manual actuating procedure including a manual gripping of said safety member and removal thereof from said exterior position prior to said movement of said tubular member toward said forward housing member.

4. An autoinjector as defined in claim 3 wherein said forward housing member defines a portion of said chamber containing said medicament cartridge assembly, said rearward housing member and said tubular member forming parts of said releasable stressed spring assembly, and means for securing a forward end portion of said rearward housing member with a rearward end portion of said forward housing member so as to retain the medicament cartridge assembly contained within the latter in cooperating relation with said releasable stressed spring assembly carried by said rearward housing member.

5. An autoinjector as defined in claim 4 wherein said releasable means comprises a collet member having a flanged forward end portion and a plurality of locking elements on a rearward end portion normally biased into a locking position and operable to be moved relatively toward one another against such bias into a releasing position, said locking elements including forwardly facing locking surfaces, said rearward housing member including rearwardly facing locking surface means disposed to be engaged by the forwardly facing locking surfaces of said locking elements when in said locking position, said spring means comprising a compression coil spring compressed between an interior rearwardly facing abutment surface on said rearward housing member and the flanged forward end portion of said collet, said releasing means comprising inclined surfaces on said locking elements and cooperating surface means on said tubular releasing member for engaging said inclined surfaces and moving said locking elements toward one another in response to the movement of said tubular releasing member from said storage position into said actuating position to thereby disengage the forwardly facing locking surfaces of said locking elements with said rearwardly facing locking surface means.

6. An autoinjector as defined in claim 5 wherein said tubular releasing member includes a hollow rearward end portion or reduced diameter disposed rearwardly of said rearward housing member adapted to be thumb engaged to effect movement of said tubular releasing member from said storage position to said actuating position.

7. An autoinjector as defined in claim 6 wherein said safety member includes a forwardly extending pin portion disposed through the rearward end portion of said releasing member and between the locking elements of said collet when in said storage position so as to prevent relative movement of said locking elements toward one another out of the storage position thereof.

8. An autoinjector as defined in claim 7 wherein said means for detachably securing said housing cap structure is operable to enable said housing cap structure to be manually detachable from secured relation with said housing body assembly only by the application of two different manual actions relatively therebetween.

9. An autoinjector as defined in claim 8 wherein the two manual actions enabling said housing cap structure to be manually detached from secured relation with said housing body assembly by said means for detachably securing said housing cap structure comprises a combination of (1) a relative longitudinal movement in a direction to move the housing cap structure and body assembly apart and (2) a relative turning movement.

10. An autoinjector as defined in claim 9 wherein said container is mounted within said chamber of said housing body assembly for retention in the storage position thereof wherein a forward end thereof is disposed at the needle extension end of said housing body assembly, said container having an elastomeric stopper at said forward end thereof and a piston slidably sealingly mounted within a rearward end portion thereof, said liquid medicament and said hypodermic needle being mounted within said container between said stopper and said piston when in said storage position, said piston being movable by said spring means from the storage position thereof to an extended position during which said hypodermic needle is moved through said stopper and into the tissue of the user and said liquid medicament is moved through said hypodermic needle into the tissue of the user.

11. An autoinjector as defined in claim 3 wherein said means for detachably securing said housing cap structure is operable to enable said housing cap structure to be manually detachable from secured relation with said housing body assembly only by the application of two different manual actions relatively therebetween.

12. An autoinjector as defined in claim 11, wherein the two manual actions enabling said housing cap structure to be manually detached from secured relation with said housing body assembly by said means for detachably securing said housing cap structure comprises a combination of (1) a relative longitudinal movement in a direction to move the housing cap structure and body assembly apart and (2) a relative turning movement.

13. An autoinjector particularly suited to be carried on the person of a user comprising

housing means defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen, said housing means including a housing body assembly of elongated generally cylindrical configuration having a needle extension end and an opposite end and a separate housing cap structure of elongated generally cylindrical configuration having an open end and an opposite closed end,

an elongated clip having one end fixed to the exterior of said cap structure adjacent the closed end thereof so as to extend longitudinally therealong and a free end biased to engage with the exterior of said cap structure adjacent the open end thereof whereby said clip serves to secure said cap structure within a pocket on the person of a user,

means between said housing body assembly and said housing cap structure for detachably securing said separate housing cap structure in open ended telescopic relation with an opposite end portion of said housing body assembly so that the latter is secured together with said cap structure within such pocket by said clip,

said housing body assembly defining an interior chamber,

a medicament cartridge assembly mounted in a storage position within said interior chamber adjacent the needle extension end of said housing body assembly including a container, a liquid medicament within said container and a hypodermic needle disposed in a storage position and movable therefrom into an extended operative position,

a releasable stressed spring assembly carried by said housing body assembly adjacent the opposite end thereof including spring means, releasable means for retaining said spring means in a stressed storage position within said chamber and releasing means operable in response to a predetermined manual actuating procedure to release said releasable means so that said spring means moves (1) said hypodermic needle into said extended operative position during which the hypodermic needle moves outwardly of the needle extension end of said housing body assembly through the skin and into the adjacent tissue of a user and (2) said liquid medicament outwardly through said hypodermic needle into the tissue of the user,

said releasing means including manually movable means extending beyond the opposite end portion of said housing body assembly into an exterior position suitable for manual engagement so as to be manually moved during the manual actuating procedure to which said releasing means is responsive to release said releasable means,

said housing cap structure covering said manually movable means when said housing cap structure is secured to said housing body assembly so as to prevent the manual engagement of said manually movable means without said housing cap structure being detached from said housing body assembly thereby enabling said housing cap structure to serve the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user'"'"'s pocket and (2) alleviating the likelihood of an unwanted release of the releasable means with a resultant unwanted movement of said hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle,

said housing body assembly including a forward housing member defining the needle extension end thereof and a rearward housing member fixed to said forward housing member,

said manually movable means including a movable releasing member mounted for movement from a storage position into an actuating position,

said predetermined manual actuating procedure to which said releasing means is responsive to release said releasable means including a relative movement of said releasing member with respect to said rearward housing member into said actuating position by manually moving the same toward said forward housing member with a thumb while the needle extension end of said housing body assembly is retained in an operative position with the skin of the user at the location where the injection is to take place,

said forward housing member defines a portion of said chamber containing said medicament cartridge assembly,

said rearward housing member forming part of said releasable stressed spring assembly, and

means for securing a forward end portion of said rearward housing member with a rearward end portion of said forward housing member so as to retain the medicament cartridge assembly contained within the latter in cooperating relation with said releasable stressed spring assembly carried by said rearward housing member,

said container being mounted within said chamber of said housing body assembly for movement from the storage position thereof into an extended position within said chamber of said housing body assembly,

a hub assembly connecting a rearward end of said hypodermic needle with a forward end of said container for movement therewith,

a resilient sheath extending over said hypodermic needle when said hypodermic needle is in the storage position thereof,

said container having a piston slidably sealingly mounted in a rearward end portion thereof in engagement with the liquid medicament within said container operable to be moved by said spring means into an extended position during which (1) said container is moved into its extended position, (2) said hypodermic needle is moved with said container through said sheath and into the tissue of the user while said sheath is compressed within said chamber of said housing body assembly and (3) said liquid medicament is moved out of said hypodermic needle into the tissue of the user,

said hub assembly having a seal therein normally sealing the liquid medicament from contact with said needle operable to burst in response to the initial portion of the movement of said piston within said container.

14. An autoinjector as defined in claim 13 wherein said releasable means comprises a collet member having a plurality of annularly spaced elongated fingers connected with the rearward end portion thereof for radially inward movement from a collet retaining position into a collet releasing position, said fingers having exterior collet retaining surfaces on outer portions thereof and interior collet releasing surfaces on inner portions thereof, cooperating collet retaining surface means on said rearward housing member engaging said exterior collet retaining surfaces for (1) retaining (a) said collet against forward movement and (b) said spring

means in stressed condition when said releasing member is in said storage position and (2) for enabling the stressed condition of said spring means to effect (a) radially inward movement of said fingers and (b) forward movement of said collet in response to the movement of said releasing member into said actuating position.

15. An autoinjector as defined in claim 14 wherein said releasing member includes (1) a forward portion having exterior surface means engaging said interior collet releasing surfaces when said releasing member is in said storage position, (2) a button portion spaced rearwardly of said forward portion for engagement by the thumb of the user, and (3) a slender stem portion connected between said forward portion and said button portion.

16. An autoinjector as defined in claim 13 wherein said means for detachably securing said housing cap structure is operable to enable said housing cap structure to be manually detachable from secured relation with said housing body assembly by the application of a simple manual turning movement relatively therebetween.

17. An autoinjector particularly suited to be carried on the person of a user comprising

housing means defining an exterior configuration of a size and shape approximately the same as that of a conventional fountain pen, said housing means including a housing body assembly of elongated generally cylindrical configuration having a needle extension end and an opposite end and a separate housing cap structure of elongated generally cylindrical configuration having an open end and an opposite closed end,

an elongated clip having one end fixed to the exterior of said cap structure adjacent the closed end thereof so as to extend longitudinally therealong and a free end biased to engage with the exterior of said cap structure adjacent the open end thereof whereby said clip serves to secure said cap structure within a pocket on the person of a user,

means between said housing body assembly and said housing cap structure for detachably securing said separate housing cap structure in open ended telescopic relation with an opposite end portion of said housing body assembly so that the latter is secured together with said cap structure within such pocket by said clip,

said housing body assembly defining an interior chamber,

a medicament cartridge assembly mounted in a storage position within said interior chamber adjacent the needle extension end of said housing body assembly including a container, a liquid medicament within said container and a hypodermic needle disposed in a storage position and movable therefrom into an extended operative position,

a releasable stressed spring assembly carried by said housing body assembly adjacent the opposite end thereof including spring means, releasable means for retaining said spring means in a stressed storage position within said chamber and releasing means operable in response to a predetermined manual actuating procedure to release said releasable means so that said spring means moves (1) said hypodermic needle into said extended operative position during which the hypodermic needle moves outwardly of the needle extension end of said housing body assembly through the skin and into the adjacent tissue of a user and (2) said liquid medicament outwardly through said hypodermic needle into the tissue of the user,

said releasing means including manually movable means extending beyond the opposite end portion of said housing body assembly into an exterior position suitable for manual engagement so as to be manually moved during the manual actuating procedure to which said releasing means is responsive to release said releasable means,

said housing cap structure covering said manually movable means when said housing cap structure is secured to said housing body assembly so as to prevent the manual engagement of said manually movable means without said housing cap structure being detached from said housing body assembly thereby enabling said housing cap structure to serve the dual purposes of (1) facilitating the securement of the housing cap structure and body assembly with the user'"'"'s pocket and (2) alleviating the likelihood of an unwanted release of the releasable means with a resultant unwanted movement of said hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle,

said container being mounted within said chamber of said housing body assembly for movement from the storage position thereof into an extended position within said chamber of said housing body assembly,

said hypodermic needle being connected at a rearward end thereof with a forward end of said container for movement therewith,

a resilient sheath extending over said hypodermic needle when said hypodermic needle is in the storage position thereof,

said container having a piston slidably sealingly mounted in a rearward end portion thereof in engagement with the liquid medicament within said container operable to be moved by said spring means into an extended position during which (1) said container is moved into its extended position, (2) said hypodermic needle is moved with said container through said sheath and into the tissue of the user while said sheath is compressed within said chamber of said housing body assembly and (3) said liquid medicament is moved out of said hypodermic needle into the tissue of the user.

18. An autoinjector as defined in claim 17 wherein said manually movable means comprises a movable releasing member mounted for movement from a storage position into an actuating position, said releasable means comprises a collet member having a plurality of annularly spaced elongated fingers connected with the rearward end portion thereof for radially inward movement from a collet retaining position into a collet releasing position, said fingers having exterior collet retaining surfaces on outer portions thereof and interior collet releasing surfaces on inner portions thereof, cooperating collet retaining surface means on said rearward housing member engaging said exterior collet retaining surfaces for (1) retaining (a) said collet against forward movement and (b) said spring means in stressed condition when said releasing member is in said storage position and (2) for enabling the stressed condition of said spring means to effect (a) radially inward movement of said fingers and (b) forward movement of said collet in response to the movement of said releasing member into said actuating position.

19. An autoinjector as defined in claim 18 wherein said releasing member includes (1) a forward portion having exterior surface means engaging said interior collet releasing surfaces when said releasing member is in said storage position, (2) a button portion spaced rearwardly of said forward portion for engagement by the thumb of the user, and (3) a slender stem portion connected between said forward portion and said button portion.

20. An autoinjector as defined in claim 17 wherein said needle is connected with said container by a hub assembly having a seal therein normally sealing the liquid medicament from contact with said needle operable to burst in response to the initial portion of the movement of said piston within said container.