Implantable device for the dosed administration of medicaments to the human body

• US 5,085,656 A
• Filed: 05/09/1990
• Issued: 02/04/1992
• Est. Priority Date: 05/10/1989
• Status: Expired due to Term

• Current Assignee: Palyon Medical Corporation
• Original Assignee: Annemarie Schlogl GmbH & Co., KG
• Inventors: Polaschegg, Hans-Dietrich
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US07/521,128
• Time in Patent Office: 636 Days
• Field of Search: 119/890.1, 119/891.1, 119/131, 119/132, 119/141
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2005/1655 Filter with fibers, e.g. filtering element in form of hollow fibers
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

An implantable device for the dosed administration of medicaments to the human body includes a first chamber for storing a medicament and having a refill opening sealed by a pierceable septum and an outlet opening communicating with an outlet catheter, a second chamber separated from the first chamber by a flexible diaphragm which serves to apply pressure to the medicament, and a hollow fiber capillary filter disposed at the outlet opening of the first chamber to act as a filter.

Claims

1. An implantable device (1) for the dosed administration of medicaments to the human body, comprising

a first chamber (4) for storing a medicament,

said chamber being provided with a refill opening (12'"'"') sealed by means of a pierceable septum (12), and

connected via an outlet opening (6) to an outlet catheter (8);

and

a second chamber (5)

which is separated by a flexible diaphragm (3) from said first chamber (4) and

serves to apply pressure via said diaphragm (3) to said medicament provided in said first chamber (4), characterized in

that a porous hollow fiber capillary (15) disposed at the outlet opening of said first chamber (4) is provided as a filter.

2. An implantable device (1) according to claim 1, characterized in that an outlet reducing means (7) connecting said outlet opening (6) to said outlet catheter (8) is provided, one end of said outlet reducing means (7) being disposed adjacent said outlet opening (6) and connected to an end of said porous hollow-fiber capillary (15).

3. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) is guided through the outlet opening (6) into said first chamber (4).

4. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) is inserted inside said first chamber (4) into a groove (16) which is disposed above said diaphragm (3).

5. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) is disposed in at least one winding in said first chamber (4).

6. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) has an inner diameter of about 200 μ

m.

7. An implantable device (1) according to claim 6, characterized in that said hollow fiber capillary (15) has an outer diameter of about 280 μ

m.

8. An implantable device (1) according to claim 1, characterized in that a conventional dialyzer diaphragm of polysulfone is used as said hollow fiber capillary (15).

9. An implantable device (1) according to claim 1, characterized in that a diaphragm which is usable for plasma filtration or plasma fractionation and has a higher exclusion capacity is employed as said hollow fiber capillary (15).

10. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) is closed on one side.

11. An implantable device (1) according to claim 2, characterized in that said hollow fiber capillary (15) is adhered to an end of said outlet reducing means (7).

12. An implantable device (1) according to claim 11, characterized in that polyurethane is used as an adhesive for adhering said hollow fiber capillary to said end of said outlet reducing means (7).

20. An implantable device (1) according to claim 1, characterized in that said hollow fiber capillary (15) is closed on one side.

13. An implantable device (1) for the dosed administration of medicaments to the human body, comprising

a first chamber (4) for storing a medicament, said chamber being provided with a refill opening (12'"'"') sealed by means of a pierceable septum (12), and connected via an outlet opening (6) to an outlet catheter (8);

and

a second chamber (5)

which is separated by a flexible diaphragm (3) from said first chamber (4) and

serves to apply pressure via said diaphragm (3) to said medicament provided in said first chamber (4),

characterized in that porous hollow fiber capillary (15) guided through the outlet opening (6) into said first chamber (4) is provided as a filter.

14. An implantable device (1) according to claim 13, characterized in that an outlet reducing means (7) connecting said outlet opening (6) to said outlet catheter (8) is provided, one end of said outlet reducing means (7) being disposed adjacent said outlet opening (6) and connected to an end of said porous hollow fiber capillary (15).

15. An implantable device (1) according to claim 13, characterized in that said hollow fiber capillary (15) is inserted inside said first chamber (4) into a groove (16) which is disposed above said diaphragm (3).

16. An implantable device (1) according to claim 13, characterized in that said hollow fiber capillary (15) is closed on one side.

17. An implantable device (1) for the dosed administration of medicaments to the human body, comprising

a first chamber (4) for storing a medicament,

said chamber being provided with a refill opening (12'"'"') sealed by means of a pierceable septum (12), and connected via an outlet opening (6) to an outlet catheter (8);

and

a second chamber (5)

which is separated by a flexible diaphragm (3) from said first chamber (4) and

serves to apply pressure via said diaphragm (3) to said medicament provided in said first chamber (4),

characterized in that a porous hollow fiber capillary (15) disposed at the outlet opening of said first chamber (4) is provided as a filter, wherein said hollow fiber capillary (15) is inserted inside said first chamber (4) into a groove (16) which is disposed above said diaphragm (3).

18. An implantable device (1) according to claim 17, characterized in that outlet reducing means (7) connecting said outlet opening (6) to said outlet catheter (8) is provided, one end of said outlet reducing means (7) being disposed adjacent said outlet opening (6) and connected to an end of said porous hollow fiber capillary (15).

19. An implantable device (1) according to claim 17, characterized in that said hollow fiber capillary (15) is guided through the outlet opening (6) into said first chamber (4).