Steroid eluting intramuscular lead

• US 5,086,787 A
• Filed: 02/28/1991
• Issued: 02/11/1992
• Est. Priority Date: 12/06/1989
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Grandjean, Pierre-Andre, Bourgeois, Ivan, Lee, Philip H. J.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/662,526
• Time in Patent Office: 348 Days
• Field of Search: 128/419 P, 128/784, 128/785, 128/786, 606/228, 606/229, 606/330, 606/331
• US Class Current: 607/120
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/152 branching on and drawing blood from a blood vessel
• CPC Class Codes: A61M 60/191 mechanically acting upon the outside of the patient's native heart, e.g. compressive structures placed around the heart
• CPC Class Codes: A61M 60/274 the inlet and outlet being the same, e.g. para-aortic counter-pulsation blood pumps
• CPC Class Codes: A61M 60/289 Devices for mechanical circulatory actuation assisting the residual heart function by means mechanically acting upon the patient's native heart or blood vessel structure, e.g. direct cardiac compression [DCC] devices
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/878 Electrical connections within the patient's body
• CPC Class Codes: A61M 60/882 Devices powered by the patient, e.g. skeletal muscle powered devices
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium
• CPC Class Codes: A61N 1/36042 of grafted tissue, e.g. skeletal muscle

Abstract

An intramuscular lead for electrically stimulating muscle tissue particularly configured for a cardiac assist system powered by surgically modified skeletal muscle tissue. Electrical stimulation is supplied via the intramuscular lead to cause contraction of the skeletal muscle in synchrony with the natural or artificially paced heart rate and timed to obtain the desired hemodynamic effect. The improved lead has an electrode which is embedded in the skeletal muscle. The stimulation threshold of the skeletal muscle is held relatively low by the action of a glucocorticosteroid imbedded within the strand of suture material. A spacer coil of biocompatible material is coiled around the strand of suture material, such that the turns of both coils are substantially interleaved. The spacer coil is saturated with a specific agent such as steroid or antibiotic. The compression movement of the muscle tissue and the electrode coil against the spacer coil will cause the drug to be dispensed therefrom.

Claims

1. An implantable lead for stimulation of a skeletal muscle comprising:

A. terminal connector means;

B. conductor means electrically coupled to said terminal connector means, and insulated from the bodily fluids and tissues;

C. electrode means electrically coupled to said electrical conductor means for transferring electrical energy to the body tissue;

D. spacer means for storing drug and for allowing it to be gradually eluted; and

E. said electrode means forming a coil, and said spacer means also forming a coil, wherein at least one turn of said spacer means is interleaved with the turns of said electrode means.

2. The lead according to claim 1, further including an elongated strand of biocompatible material connected to said electrode means;

and wherein said electrode means and said spacer means are coiled, at least partially around a portion of said strand.

3. The lead according to claim 2, wherein said strand is treated with elutable drug.

4. The lead according to claim 3, wherein said drug stored in said spacer means is different than said drug stored in said strand.

5. The lead according to claim 2, wherein said drug stored in said spacer means is similar to said drug stored in said strand.

6. The lead according to claim 5, wherein said drug is a glucocorticosteroid.

7. The lead according to claim 5, wherein said drug is a antibiotic.