Transdermal drug patch with conductive fibers

• US 5,087,240 A
• Filed: 10/30/1989
• Issued: 02/11/1992
• Est. Priority Date: 08/18/1983
• Status: Expired due to Term

• Current Assignee: Drug Delivery Systems Incorporated
• Original Assignee: Drug Delivery Systems Incorporated
• Inventors: Sibalis, Dan
• Primary Examiner(s): Shay, Randy Citrin
• Application Number:
  US07/428,478
• Time in Patent Office: 834 Days
• Field of Search: 128/783, 128/798, 128/799, 128/802, 128/803, 604/20
• US Class Current: 604/20
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An improved transdermal drug applicator for application to a living body for the migration of at least one medicament through the skin into the blood stream embodying at least two electrode elements forming the applicator and with the electrodes separated from each other by insulating means. A reservoir means, in at least one of said electrode elements of said applicator, containing said medicament; and a circuit, including a power source, for supplying electric power to said electrodes and such reservoir means. Suitable cover means partially enclosed at least said reservoir means, and adhesive means affixes the applicator to the skin, so as to complete an electrical circuit through the skin when the applicator is affixed thereto, thus creating at least one physico/chemical mass transfer phenomenon which causes said medicament to migrate through the skin.

Claims

1. A transdermal drug patch for delivery of at least one drug to a living body through the skin into the bloodstream comprising:

at least two electrodes separated from each other;

drug reservoir means electrically connected to at least one of said electrodes of said patch for containing the at least one drug, said reservoir means including a medicament-transfer zone for placement at the skin;

circuit means, including an electrical power source for supplying electric power to said electrodes and said reservoir means;

cover means partially enclosing at least said reservoir means;

adhesive means in juxtaposition to said reservoir means for affixing said patch to the skin, whereby when said patch is affixed to the skin the at least one drug is delivered to the skin; and

a plurality of electrically conductive fiber means connected with said circuit means and traversing said reservoir means for imposing electrical potential between said at least one of said electrodes and the skin so as to substantially bypass the at least one medicament contained in said reservoir means, wherein said electrically conductive fibers bring the electrical potential more directly to the skin where the drug delivery takes place; and

aid in reinforcing the drug patch construction.

2. A transdermal drug patch as in claim 1, wherein said electrodes are generally of the same construction.

3. A transdermal drug patch as in claim 1, wherein said electrodes are of differing constructions.

4. A transdermal drug patch as in claim 1, wherein the electrodes are of different size.

5. A transdermal drug applicator according to claim 1, wherein said drug reservoir means contain different drugs.

6. The transdermal drug patch as in claim 1, wherein said fiber means are elongated in shape.

7. The transdermal drug patch as in claim 1, wherein said fiber means are shaped in a tapered conical configuration having a base and an apex.

8. The transdermal drug patch as in claim 1, wherein the drug reservoir means contains fiber means extending between at least one electrode and a point near the medicament transfer zone.

9. The transdermal drug patch as in claim 1, further including a semipermeable membrane coextensive and covering the medicament zone of said drug patch.

10. The transdermal drug patch as in claim 1, wherein the conductive fiber means are made of carbon.

11. The transdermal drug patch as in claim 1, wherein the conductive fiber means are made of graphite.

12. The transdermal drug patch as in claim 1, wherein the conductive fiber means are made of a conductive plastic comprising carbon.

13. The transdermal drug patch as in claim 1, wherein the drug reservoir means is flexible.

14. The transdermal drug patch as in claim 1, wherein the electrodes are flexible.

15. The transdermal drug patch as in claim 1, wherein the cover means is flexible.

16. A transdermal drug patch for delivery of at least one drug to a living body through the skin into the bloodstream comprising:

at least two electrodes separated from each other;

drug reservoir means electrically connected to at least one of said electrodes of said patch for containing the at least one drug, said reservoir means including a medicament-transfer zone for placement at the skin;

circuit means including an electrical power source for supplying electric power to said electrodes and said reservoir means;

cover means partially enclosing at least said reservoir means;

adhesive means in juxtaposition to said reservoir means for affixing said patch to the skin, whereby when said patch is affixed to the skin, the at least one drug is delivered to the skin; and

a plurality of electrically conductive fibers connected with said circuit means and traversing said reservoir means for imposing electrical potential between said at least one of said electrodes and the skin so as to substantially bypass the at least one medicament contained in said reservoir means, wherein said electrically conductive fibers bring the electrical potential more directly to the skin where the drug delivery takes place; and

wherein the drug-reservior means includes a high concentration drug zone containing a high concentration of the at least one drug and a low concentration drug zone containing a low concentration of the at least one drug and a semipermeable membrane positioned between the low and high concentration drug zones, with said high concentration drug located between at least one electrode and said membrane.

17. The transdermal drug patch as in claim 16, wherein the fibers traverse at least one of said drug zones.

18. The transdermal drug patch as in claim 17, wherein the conductive fibers traverse both the high concentration drug zone and the low concentration drug zone and extend from at least one electrode.

19. The transdermal drug patch as in claim 16, wherein the conductive fibers include a first group which traverse the high concentration drug zone and a second group which traverse the low concentration drug zone.

20. A transdermal drug patch for delivery of at least one drug to a living body through the skin into the bloodstream comprising:

at least two electrodes separated from each other;

drug reservoir means electrically connected to at least one of said electrodes of said patch for containing the at least one drug, said reservoir means including a medicament-transfer zone for placement at the skin;

circuit means, including an electrical power source for supplying electric power to said electrodes and said reservoir means;

cover means partially enclosing at least said reservoir means;

adhesive means in juxtaposition to said reservoir means for affixing said patch to the skin, whereby when said patch is affixed to the skin, the at least one drug is delivered to the skin; and

a plurality of electrically conductive fibers connected with said circuit means and traversing said reservoir means for imposing electrical potential between said at least one said electrodes and the skin so as to substantially bypass the at least one medicament contained in said reservoir means, wherein said electrically conductive fibers bring the electrical potential more directly to the skin medicament-transfer zone where the drug delivery takes place; and

including a semipermeable membrane coextensive with and covering medicament-transfer zone of said patch, said semipermeable membrane comprising a microporous adhesive material.