Myocardial iontophoresis
First Claim
1. An implantable iontophoretic delivery system for use in applying medicinal materials rapidly to specific tissue sites of interest comprising:
- a source of electrical current;
pulse generating means associated with the source of electric current for generating a series of electric current pulses;
first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current, wherein the first electrode further includes means adapted to receive, contain and dispense medicinal materials from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses supplied from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode to cause infusion of the medicinal material in the desired direction;
storage means for storing a supply of the medicinal materials;
conduit means connecting the storage means with the first electrode;
pump means for supplying an amount of the medicinal materials from the storage means to the first electrode on demand;
circuit means connected to the source for supplying current pulses generated by the pulse generating means to the electrodes;
condition sensing means for sensing medical conditions in the tissue of interest requiring application of the medicinal materials to the tissue of interest; and
control means for activating and deactivating the pump means and pulse generating means in response to sensed conditions.
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Accused Products
Abstract
An implantable iontophoretic delivery system for use in applying medicinal materials rapidly to specific subcutaneous tissue sites of interest in conjunction with an implanted defibrillator is disclosed which uses a subcutaneously situated pouch for supplying medication in conjunction with a pair of defibrillator electrodes connected to a power source. One of the electrodes is located proximately with respect to the tissue of interest and is designed to dispense the medication of interest utilizing controlled electrical pulses. The pouch is connected with the administering electrode of the electrode system via pumping mechanism.
508 Citations
8 Claims
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1. An implantable iontophoretic delivery system for use in applying medicinal materials rapidly to specific tissue sites of interest comprising:
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a source of electrical current; pulse generating means associated with the source of electric current for generating a series of electric current pulses; first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current, wherein the first electrode further includes means adapted to receive, contain and dispense medicinal materials from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses supplied from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode to cause infusion of the medicinal material in the desired direction; storage means for storing a supply of the medicinal materials; conduit means connecting the storage means with the first electrode; pump means for supplying an amount of the medicinal materials from the storage means to the first electrode on demand; circuit means connected to the source for supplying current pulses generated by the pulse generating means to the electrodes; condition sensing means for sensing medical conditions in the tissue of interest requiring application of the medicinal materials to the tissue of interest; and control means for activating and deactivating the pump means and pulse generating means in response to sensed conditions. - View Dependent Claims (2, 3)
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4. An implantable iontophoretic delivery system for use in applying cardiac medications rapidly to specific arrhythmogenic heart tissue sites of interest in conjunction with the operation of an automatic implantable cardioverter/defibrillator (AICD) comprising:
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a source of electrical current; pulse generating means associated with the source of electrical current for generating electric current pulses; first and second electrodes adapted to be proximately positioned with respect to the tissue site of interest and connected by leads to the source of electrical current for the implantable defibrillator, wherein the first electrode further includes means adapted to receive, contain and dispense cardiac medication from a stored supply thereof into proximate tissue of interest in accordance with a series of benign electric pulses from the pulse generating means and wherein the second electrode is disposed to cooperate with the first electrode in the infusion of medication as desired; storage means for storing a supply of cardiac medication; conduit means connecting the storage means with the first electrode; pump means for supplying an amount of the medication from the storage means to the first electrode on demand; circuit means connected to the source of electrical current for supplying defibrillating current pulses from the pulse generating means and a series of cardiac medication infusing current pulses from the pulse generating means to the electrodes; condition sensing means for sensing medical conditions in the tissue of interest requiring defibrillation and/or application of the cardiac medication to the tissue of interest; and control means for activating and deactivating the pump means and both the defibrillation and/or the medicating infusing pulsing in response to sensed conditions or in fixed interval form. - View Dependent Claims (5, 6)
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7. A method of rapidly applying cardiac medication to specific arrhythmogenic heart tissue sites of interest comprising the steps of:
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receiving a signal indicative of a cardiac condition requiring the application of the medication; causing an amount of the mediation to be pumped from an implanted supply thereof to a first electrode of a pair including first and second electrodes proximately positioned with respect to the tissue site of interest and connected to a source of electrical energy; and causing a series of benign electrical current pules to be generated from the source of electrical energy and applied through the electrodes in a manner which produces an infusion of the medication from the first electrode into the tissue. - View Dependent Claims (8)
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Specification