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Cytotoxic drug conjugates and their delivery to tumor cells

  • US 5,087,616 A
  • Filed: 08/06/1987
  • Issued: 02/11/1992
  • Est. Priority Date: 08/07/1986
  • Status: Expired due to Fees
First Claim
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1. A therapeutic chemical conjugate including EGF as a first moiety, and a second moiety linked covalently to the EGF, said second moiety comprising a plurality of repeating units, each unit having the structure ##STR12## where L is selected from the group consisting of polyglutamic acid and polyaspartic acid, and T is selected from the group consisting of anthracycline drugs, bleomycin, melphalan, chlorambucil, cisplatin, adriamycin, daunomycin, and daunorubicin, and where said conjugate has a molecular weight of between 10,000 and 100,000 D and is effective in target cells in vivo and is internalized by tumor cells whereby the latter are inhibited or destroyed.

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