Multiple wavelength light photometer for non-invasive monitoring
First Claim
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1. An improved multiple wavelength light spectrophotometer for non-invasive monitoring of a body organ in vivo comprising:
- (a) a single light source emitting radiation at at least four near infrared wavelengths including a lamp powered by AC-timed pulses;
(b) an optical fiber transmitting the near infrared radiation emitted from said single light source to a body organ;
(c) an optical fiber receiving near infrared radiation transmitted through the organ by said transmitting optical fiber (b) and conducting the received infrared radiation to a radiation detector (d), which receiving optical fiber is disposed in relation to said transmitting optical fiber (b) so that the two optical fibers are aligned or form an angle therebetween of up to 180°
;
(d) a radiation detector having means for branching the radiation conducted from optical fiber (c) into at least four different wavelengths, comprising a system of at least four interference filters and complimentary photomultipliers whereby at least four individual signals corresponding to said at least four different wavelengths are produced and transmitted to amplifier means (e);
(e) amplifier means for converting said at least four individual signals to continuous signals; and
(f) data acquisition means connected to said amplifier means for converting the continuous signals into display signals representing values of physiological parameters, including a microprocessor utilizing the following algorithm to correct the display signals for light diffusion effects;
space="preserve" listing-type="equation">δ
OD.sub.app (λ
)=(C.sub.2 λ
-2C.sub.3 λ
A)(a.sub.1 λ
δ
V+a.sub.2 λ
δ
O+a.sub.3 λ
δ
R)+Aγ
(C.sub.2o λ
-AC.sub.3o λ
)δ
S, whereinODapp is the apparent optical density at a given wavelength (λ
);
A is absorbance;
S is the blood volume;
R is the redox state of cyt aa3 ;
O is the hemoglobin oxygen saturation; and
V is the heme value.
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Abstract
A multiple wavelength light spectrophometer for non-invasive monitoring of a body organ in vivo comprising: a single pulsed light source, optical fibers for transmitting to and receiving the infrared radiation from the organ, a radiation detector capable of branching received radiation into several different wavelengths, an amplifier, and a data acquisition system including a microprocessor capable of compensating for light diffusion effects by employing a specific algorithm.
485 Citations
6 Claims
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1. An improved multiple wavelength light spectrophotometer for non-invasive monitoring of a body organ in vivo comprising:
-
(a) a single light source emitting radiation at at least four near infrared wavelengths including a lamp powered by AC-timed pulses; (b) an optical fiber transmitting the near infrared radiation emitted from said single light source to a body organ; (c) an optical fiber receiving near infrared radiation transmitted through the organ by said transmitting optical fiber (b) and conducting the received infrared radiation to a radiation detector (d), which receiving optical fiber is disposed in relation to said transmitting optical fiber (b) so that the two optical fibers are aligned or form an angle therebetween of up to 180°
;(d) a radiation detector having means for branching the radiation conducted from optical fiber (c) into at least four different wavelengths, comprising a system of at least four interference filters and complimentary photomultipliers whereby at least four individual signals corresponding to said at least four different wavelengths are produced and transmitted to amplifier means (e); (e) amplifier means for converting said at least four individual signals to continuous signals; and (f) data acquisition means connected to said amplifier means for converting the continuous signals into display signals representing values of physiological parameters, including a microprocessor utilizing the following algorithm to correct the display signals for light diffusion effects;
space="preserve" listing-type="equation">δ
OD.sub.app (λ
)=(C.sub.2 λ
-2C.sub.3 λ
A)(a.sub.1 λ
δ
V+a.sub.2 λ
δ
O+a.sub.3 λ
δ
R)+Aγ
(C.sub.2o λ
-AC.sub.3o λ
)δ
S,wherein ODapp is the apparent optical density at a given wavelength (λ
);A is absorbance; S is the blood volume; R is the redox state of cyt aa3 ; O is the hemoglobin oxygen saturation; and V is the heme value. - View Dependent Claims (2, 3, 4, 5)
-
-
6. An improved multiple wavelength light spectrophotometer for non-invasive monitoring of a body organ in vivo comprising:
-
(a) a single light source emitting radiation at at least four near infrared wavelengths including a lamp powered by AC-timed pulses; (b) an optical fiber transmitting the near infrared radiation emitted from said single light source to a body organ; (c) an optical fiber receiving near infrared radiation transmitted through the organ by said transmitting optical fiber (b) and conducting the received infrared radiation to a radiation detector (d), which receiving optical fiber is disposed in relation to said transmitting optical fiber (b) so that the two optical fibers are aligned or form an angle therebetween of up to 180°
;(d) a radiation detector having means for branching the radiation conducted from optical fiber (c) into at least four different wavelengths, comprising a system of a single interference filter variable in the range of 750 to 900 nm and complimentary photomultiplier whereby at least four individual signals corresponding to said at least four different wavelengths are produced and transmitted to amplifier means (e); (e) amplifier means for converting said at least four individual signals to continuous signals; and (f) data acquisition means connected to said amplifier means for converting the continuous signals into display signals representing values of physiological parameters, including a microprocessor utilizing the following algorithm to correct the display signals for light diffusion effects;
space="preserve" listing-type="equation">δ
OD.sub.app (λ
)=(C.sub.2 λ
-2C.sub.3 λ
A)(a.sub.1 λ
δ
V+a.sub.2 λ
δ
O+a.sub.3 λ
δ
R)+Aγ
(C.sub.2o λ
-AC.sub.3o λ
)δ
S,wherein ODapp is the apparent optical density at a given wavelength (λ
);A is absorbance; S is the blood volume; R is the redox state of cyt aa3 ; O is the hemoglobin oxygen saturation; and V is the heme value.
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Specification
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Current AssigneeSclavo SPA
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Original AssigneeSclavo SPA
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InventorsFerrari, Marco, Giannini, Ivo, de Resmini, Amilcare C., Fasella, Paolo
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Primary Examiner(s)Howell, Kyle L.
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Assistant Examiner(s)Hanley, John
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Application NumberUS07/161,206Time in Patent Office1,463 DaysField of Search128/633, 128/634, 128/664-666US Class Current600/323CPC Class CodesA61B 5/0059 using light, e.g. diagnosis...G01J 2001/182 with SH sample and hold cir...G01J 2001/4453 PMTG01N 2021/3129 Determining multicomponents...G01N 21/314 with comparison of measurem...G01N 2201/0696 PulsedG01N 2201/08 Optical fibres; light guidesG01N 2201/126 Microprocessor processing
